Madhi SA, Kayhty H, Kuwanda L, Holm A, Klugman KP; International Conference on AIDS (15th : 2004 : Bangkok, Thailand).

Int Conf AIDS. 2004 Jul 11-16; 15: abstract no. TuPeB4448.

Respiratory and Meningeal Pathogens Research Unit, Univ. of the Witwatersrand, Johannesburg, South Africa

Background: The immunogenicity of an effective vaccine (PncCV) for children against Streptococcus pneumoniae was evaluated. Methods: 66 HIV+ (none of who received anti-retroviral therapy) and 127 HIV-uninfected (HIV-) children were randomized to receive PncCV or placebo at a mean age (S. D.) of 1.56 (0.30)months, 2.63 (0.52)m and 3.73 (0.88)m. Antibody concentrations to each of the 9 vaccine serotypes using standardized EIA and osponophagocytic activity (OPA) against serotypes 6B, 19F and 23F were measured at a mean of 23.5 (S. D. 5.7) days following the 3rd dose of vaccine. Results: The geometric mean antibody concentrations (GMC) were significantly greater (P<0.0001) for all 9 serotypes among vaccinees compared to placebo recipients in HIV+ and HIV- children. Among vaccinees, HIV+ children had lower GMC to serotypes 1 (P=0.0001) and 18C (P=0.02), however, there was no difference in GMC for the remaining 7 serotypes. HIV+ children in CDC clinical stage N/A had similar GMC compared to HIV- children, except for a lower response to serotype 1 (P=0.006). HIV+ children with CDC clinical stage C had lower GMC to serotypes 5 (P=0.01), 9V (P=0.01), 14 (P=0.03), 18C (P=0.05) and 23F (P=0.04) compared to HIV+ children in clinical stage N/A. GMC's were paradoxically greater for serotypes 1, 4, 5, 14, 18C, 19F and 23F in HIV+ compared to HIV- placebo recipients (P<0.05). There was no difference in correlation between the antibody concentrations and opsonophagocytic activity between HIV+ and HIV- children for serotypes 6B (P=0.30), 19F (P=0.43) and 23F (P=0.38). Conclusion HIV+ vaccinees have similar quantitative and qualitative antibody responses to serotypes included in a 9-valent PncCV compared to HIV- vaccinees. However, HIV+ vaccinees with advanced AIDS have a poorer antibody response compared to asymptomatic/mildly symptomatic HIV+ vaccinees. HIV+ children, also appear to have a higher level of baseline antibody concentrations of unknown functionality.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS Vaccines
• Acquired Immunodeficiency Syndrome
• Antibody Formation
• Antigens, Bacterial
• Child
• HIV Infections
• HIV Seropositivity
• Humans
• Streptococcus pneumoniae
• immunology

Other ID:

• GWAIDS0038054

UI: 102282270

From Meeting Abstracts