Borgia P, Giorgi Rossi P, Curtale F, Mantovani J, Ferroni E, Guasticchi G, Forcina A; Health Technology Assessment International. Meeting (3rd : 2006 : Adelaide, S. Aust.).
Handb Health Technol Assess. 2006; 3: 40.
Public Health Agency Lazio Region, Via S. Costanza 53, 00185 Rome, Italy
Objectives: New vaccines target most of the meningococcus and pneumococcus strains. Aim of this study was to estimate impact of different vaccination strategies. Methods: Lazio, years 2001-2003, 5.300.000 inhabitants. Data sources: Meningitis Hospital Surveillance, Infectious Diseases Information System, Hospital Discharge Registry, Laboratory Surveillance (collecting data for N. meningitis and S. pneumoniae serotypes). Data were linked, using name and birth date. A capture-recapture latent class model was used to estimate underreporting. We reconstructed the previous history of hospitalization to identify risk factors for which the vaccination is recommended and to classify the community-acquired meningitis, probable nosocomial infections and meningitis in AIDS. Results: A total of 533 cases were identified, the capture-recapture model estimated another 120 cases; the cases with vaccine preventable aetiology were more likely to be captured , as were younger patients and community acquired cases. Of the aetiologies that could be identified, S. pneumoniae represented 36.0%, and N. meningitis 21.5%. The community acquired proportion of the pneumococcal and meningococcal meningitis is 95.3%. There were 29 community S. pneumoniae cases in children under 5 years of age, 92,8% of serotypes were included in the 7-valent vaccine. There were 27 cases with N. meningitis under 5, 45,4% of serotypes included in the 3-valent vaccine. Nine percent of the pneumococcal and meningococcal community acquired meningitis occurred in children with known risk factors (cardiovascular, immunological, congenital). Conclusion: A mass vaccination of newborns for both vaccines could prevent 12 cases, while vaccination for high risk children could prevent 5 cases.
Publication Types:
Keywords:
- Child
- Humans
- Infant, Newborn
- Italy
- Meningitis, Meningococcal
- Meningococcal Vaccines
- Pneumococcal Vaccines
- Risk Factors
- Streptococcus pneumoniae
- Vaccination
- hsrmtgs
UI: 103724806
From Meeting Abstracts