Ohno T, Hayashi T, Saito T, Ito A, Nagao T, Akagi K, Imai M; International Conference on AIDS.

Int Conf AIDS. 1994 Aug 7-12; 10: 234 (abstract no. PB0366).

Kanagawa Pref. Inst. of Health, Japan.

OBJECTIVE: Clinical relevance of HIV RNA positive rate and quantitative measurement of HIV RNA in Japanese HIV carriers and AIDS patients in various disease stages was determined using a quantitative HIV RNA assay employing the bDNA probe method (bDNA HIV). METHODS: A total of 68 subjects, who were anti-HIV positive ranging from Stage II(asymptomatic) to Stage IV C2 in the CDC classification, were selected for the study. bDNA HIV was run on the plasma specimens collected from those subjects and compared with P24 antigen test and HIV isolation in cell culture. Quantitation of HIV RNA was also carried out in the patients treated with AZT and ddI. RESULTS: Among 68 HIV infected cases, positive rate of HIV RNA, viral isolation and P24 antigen was 54.2%, 47.2% and 25.8%, respectively. Respective Positive rate of HIV RNA in Stage II and Stage IV C1 patients was 45.1% and 66.1%. The level of HIV RNA increased as the disease progressed and decreased after AZT or ddI treatment despite no significant changes observed by P24 antigen test. DISCUSSION AND CONCLUSIONS: Monitoring the prevalence of HIV RNA and quantitating HIV RNA in the HIV infected cases may be very significant in understanding of the progression of the disease or in evaluation of antiviral treatment.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS Vaccines
• Acquired Immunodeficiency Syndrome
• Evaluation Studies
• HIV
• HIV Core Protein p24
• HIV Infections
• HIV Seropositivity
• Humans
• Prevalence
• RNA
• RNA, Viral
• Zidovudine
• immunology
• methods

Other ID:

• 94369829

UI: 102208659

From Meeting Abstracts