Perez-Trallero E, Montes M, Marimon JM, Gomariz M, Lopez-Lapategui C; Interscience Conference on Antimicrobial Agents and Chemotherapy.
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 173 (abstract no. 2106).
Complejo Hosp. Donostia, San Sebastian, Spain
Antibiotic resistance in NTS is influenced by human and veterinary antibiotics use. OBJECTIVE: To determine the quinolones susceptibility patterns in NTS and its evolution through the years. Material andMETHODS: Susceptibility of NTS isolates between 1978-1997 from human stools (one strain per patient) were studied by Kirby-Bauer or broth microdilution method (NCCLS guidelines). Quinolone-resistant strains were restudied by agar dilution on Mueller Hinton agar. E. coli ATCC 25922 and S. aureus ATCC 29213 were included as controls.RESULTS: Data of 4960 out of 6754 NTS isolates were recorded. First nalidixic acid-resistant strain (NalR) was isolated in 1984 but 101 out of 126 NalR were isolated between 1995 and 1997, several years after fluoroquinolones were introduced into clinical and veterinary medicine. Although all NalR (MIC50 > 128 mg/L) were susceptible to ciprofloxacin (MIC50 and MIC90: 0.25 and 0.5 mg/L, respectively) its MICs were eightfold higher than those of nalidixic acid susceptible strains (MIC50 and MIC90: 0.03 and 0.06 mg/L, respectively). The most frequent NalR serotypes were S. enteritidis (89 out of 3984 isolates), S. hadar (22/39) and S. typhimurium (8/593).CONCLUSION: Quinolone resistance has strikingly increased in our environment in the last years although this resistance was less prevalent in NTS than in other zoonotic bacterial pathogens such as Campylobacter. [table: see text]
Publication Types:
Keywords:
- Anti-Bacterial Agents
- Ciprofloxacin
- Fluoroquinolones
- Humans
- Microbial Sensitivity Tests
- Nalidixic Acid
- Quinolones
- Salmonella
- Salmonella Infections
- Spain
Other ID:
UI: 102245088
From Meeting Abstracts