Schmidt D, Pohlmann H, Hofmann W, Schramm W, Eigler J, Guder WG; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 227 (abstract no. M.B.P.35).
Inst. Clin. Chem. Stad.-Krh. Munchen-Bogenhausen, Munich, Federal Republic of Germany
Renal complications in acquired immuno deficiency syndrome (AIDS) are a common observation. It is however not clear whether the so called AIDS-related nephropathy is a primary event of viral infection or secondary due to opportunistic infections or other accompanying complications (malignancies, heroin use). We investigated 56 patients with Hemophilia A. 42 were HIV antibody positive (Group B) between 2 and 7 years (average 4.75 years). According to the CDC classifications system 20, 16, and 6 patients belonged to group II, III and IV respectively. To detect glomerular and tubular renal dysfunction we applied a new automated program of 5 urinary parameters (total protein, IgG, albumin, alpha-1-microglobulin and N-acetyl-B-D-glucosaminidase (NAG) as well as creatinine and alpha-1-microglobulin in serum. All urinary parameters were related to creatinine to correct for different excretion rates. Serumcreatinine and alpha-1-microglobulin were normal in all patients of both groups. All urines but 2 were negative by test strip for albumin. These 2 patients (Group B) had manifest proteinuria of complete tubuloglomerular type. Of the remaining 40 Group B patients 8 had slight elevations of urinary IgG excretion, of which 3 had a simultaneous increase in urinary albumin and only one had signs of tubular proteinuria. The dysproteinurias were evenly distributed over Group II and III (CDC) patients. 4 of the Group IV patients were also normal. A statistically significant difference between Group A and B was found only for urinary IgG. Our results show that hemophilic patients without and years after infection with the HIV virus have no evidence of glomerular and tubular dysfunction. The assumption that AIDS-related nephropathy is not caused by direct viral invasion of the kidney is supported by our observation. Elevated levels for urinary IgG in absence of elevated urinary albumin are more likely of postrenal rather than of glomerular origin due to other illnesses such as opportunistic infections.
Publication Types:
Keywords:
- AIDS-Associated Nephropathy
- Alpha-Globulins
- Biological Markers
- Creatinine
- HIV Seropositivity
- Hemophilia A
- Humans
- Kidney Diseases
- Proteins
- Proteinuria
- Ureteral Diseases
- alpha-1-microglobulin
- urine
Other ID:
UI: 102176888
From Meeting Abstracts