| | This journal provides immediate access to some articles. Editorial PNAS Early Edition Nicholas R. Cozzarelli PMCID: PMC33957 Commentaries Lysozyme among the Lilliputians George D. Rose PMCID: PMC33958 Bax-induced apoptotic cell death John Pawlowski and Andrew S. Kraft PMCID: PMC33959 Antitumorigenic actions of growth hormone-releasing hormone
antagonists Rhonda D. Kineman PMCID: PMC33960 Another hormone-sensitive triglyceride lipase in fat cells? Alan R. Saltiel PMCID: PMC33961 Chemistry and biology Gregory A. Petsko PMCID: PMC33962 Perspective Quantum groups with invariant integrals Alfons Van Daele PMCID: PMC33963 The operator algebra approach to quantum groups Johan Kustermans and Stefaan Vaes PMCID: PMC33964 Physical Sciences Chemistry From the Cover:
Architecture with designer atoms: Simple
theoretical considerations F. Remacle and R. D. Levine PMCID: PMC15368 Biological Sciences Applied Biological Sciences A highly efficient and robust cell-free protein synthesis system prepared from wheat embryos: Plants apparently contain a suicide system directed at ribosomes Kairat Madin, Tatsuya Sawasaki, Tomio Ogasawara, and Yaeta Endo PMCID: PMC15369 Biochemistry Highly mutagenic replication by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis Ayelet Maor-Shoshani, Nina Bacher Reuven, Guy Tomer, and Zvi Livneh PMCID: PMC15370 Acceleration of oligomerization, not fibrillization, is a shared
property of both α-synuclein mutations linked to early-onset
Parkinson's disease: Implications for pathogenesis and therapy Kelly A. Conway, Seung-Jae Lee, Jean-Christophe Rochet, Tomas T. Ding, Robin E. Williamson, and Peter T. Lansbury, Jr. PMCID: PMC15371 Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity Shigeomi Shimizu and Yoshihide Tsujimoto PMCID: PMC15372 Molecular cloning of a 10-deacetylbaccatin
III-10-O-acetyl transferase cDNA from
Taxus and functional expression in
Escherichia coli Kevin Walker and Rodney Croteau PMCID: PMC15373 The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium Stefan Strobl, Carlos Fernandez-Catalan, Marianne Braun, Robert Huber, Hajime Masumoto, Kazuhiro Nakagawa, Akihiro Irie, Hiroyuki Sorimachi, Gleb Bourenkow, Hans Bartunik, Koichi Suzuki, and Wolfram Bode PMCID: PMC15374 Evidence for a linear search in bimolecular 3′ splice site AG selection Shuyan Chen, Karin Anderson, and Melissa J. Moore PMCID: PMC15375 NifS-directed assembly of a transient [2Fe-2S] cluster within the NifU protein Pramvadee Yuvaniyama, Jeffrey N. Agar, Valerie L. Cash, Michael K. Johnson, and Dennis R. Dean PMCID: PMC15376 In vivo selection of functional ribosomes with variations in the rRNA-binding site of Escherichia coli ribosomal protein S8: Evolutionary implications Hervé Moine, Catherine L. Squires, Bernard Ehresmann, and Chantal Ehresmann PMCID: PMC15377 Modifications of proteins by polyunsaturated fatty acid peroxidation products Hanne H. F. Refsgaard, Lin Tsai, and Earl R. Stadtman PMCID: PMC15378 Biophysics Direct localization of a β-subunit domain on the three-dimensional structure of Escherichia coli RNA polymerase Natacha Opalka, Rachel A. Mooney, Catherine Richter, Konstantin Severinov, Robert Landick, and Seth A. Darst PMCID: PMC15379 From the Cover:
Specific chemical and structural damage to proteins produced by synchrotron radiation Martin Weik, Raimond B. G. Ravelli, Gitay Kryger, Sean McSweeney, Maria L. Raves, Michal Harel, Piet Gros, Israel Silman, Jan Kroon, and Joel L. Sussman PMCID: PMC15380 From the Cover:
Sequence-specific binding of counterions to B-DNA Vladimir P. Denisov and Bertil Halle PMCID: PMC15381 Landscape approaches for determining the ensemble of folding transition states: Success and failure hinge on the degree of frustration Hugh Nymeyer, Nicholas D. Socci, and José Nelson Onuchic PMCID: PMC15382 Mechanism of the single-headed processivity: Diffusional anchoring between the K-loop of kinesin and the C terminus of tubulin Yasushi Okada and Nobutaka Hirokawa PMCID: PMC15383 RNA folding energy landscapes Shi-Jie Chen and Ken A. Dill PMCID: PMC15384 Cell Biology CopA: An Escherichia coli Cu(I)-translocating P-type ATPase Christopher Rensing, Bin Fan, Rakesh Sharma, Bharati Mitra, and Barry P. Rosen PMCID: PMC15385 Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptor Marc I. Diamond, Melissa R. Robinson, and Keith R. Yamamoto PMCID: PMC15386 Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death Tatsushi Igaki, Hirotaka Kanuka, Naohiro Inohara, Kazunobu Sawamoto, Gabriel Núñez, Hideyuki Okano, and Masayuki Miura PMCID: PMC15387 The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate Craig McCormick, Gillian Duncan, K. Tina Goutsos, and Frank Tufaro PMCID: PMC15388 Calnuc, an EF-Hand Ca2+ binding protein, specifically interacts with the C-terminal α5-helix of Gαi3 Ping Lin, Thierry Fischer, Thomas Weiss, and Marilyn Gist Farquhar PMCID: PMC15389 A Rab11-containing rapidly recycling compartment in macrophages that promotes phagocytosis Dianne Cox, Donna J. Lee, Benjamin M. Dale, Jero Calafat, and Steven Greenberg PMCID: PMC15390 A method for detecting abasic sites in living cells: Age-dependent changes in base excision repair Hani Atamna, Ivana Cheung, and Bruce N. Ames PMCID: PMC15391 Position-dependent linkages of fibronectin– integrin–cytoskeleton Takayuki Nishizaka, Qing Shi, and Michael P. Sheetz PMCID: PMC15392 Evolution Heritability of fitness in a wild mammal population Loeske E. B. Kruuk, Tim H. Clutton-Brock, Jon Slate, Josephine M. Pemberton, Sue Brotherstone, and Fiona E. Guinness PMCID: PMC15393 Functional evolution of the Ultrabithorax protein Jennifer K. Grenier and Sean B. Carroll PMCID: PMC15394 Genetics Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype Minoru Toyota, Mutsumi Ohe-Toyota, Nita Ahuja, and Jean-Pierre J. Issa PMCID: PMC15395 From the Cover:
Heterochromatic deposition of centromeric histone H3-like proteins Steven Henikoff, Kami Ahmad, J. Suso Platero, and Bas van Steensel PMCID: PMC15396 Double trans-chromosomic mice: Maintenance of two individual human chromosome fragments containing Ig heavy and κ loci and expression of fully human antibodies Kazuma Tomizuka, Tokuyuki Shinohara, Hitoshi Yoshida, Hiroshi Uejima, Atsuko Ohguma, Sonoko Tanaka, Kaoru Sato, Mitsuo Oshimura, and Isao Ishida PMCID: PMC15397 Plasmid copy-number control and better-than-random segregation genes of pSM19035 share a common regulator Ana B. de la Hoz, Silvia Ayora, Izabela Sitkiewicz, Silvia Fernández, Renata Pankiewicz, Juan C. Alonso, and Piotr Ceglowski PMCID: PMC15398 Immunology IL-18 regulates IL-1β-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1 Fernando Vidal-Vanaclocha, Giamila Fantuzzi, Lorea Mendoza, Angela M. Fuentes, Miren J. Anasagasti, Javier Martín, Teresa Carrascal, Patrick Walsh, Leonid L. Reznikov, Soo-Hyun Kim, Daniela Novick, Menachem Rubinstein, and Charles A. Dinarello PMCID: PMC15399 Involvement of decidual Vα14 NKT cells in abortion Katsura Ito, Mika Karasawa, Tetsu Kawano, Takeshi Akasaka, Haruhiko Koseki, Yasunori Akutsu, Eisuke Kondo, Souei Sekiya, Kenji Sekikawa, Michishige Harada, Masakatsu Yamashita, Toshinori Nakayama, and Masaru Taniguchi PMCID: PMC15400 Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT) Balasubramanian Arunachalam, Uyen T. Phan, Hans J. Geuze, and Peter Cresswell PMCID: PMC15401 Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP Gregory A. Taylor, Carmen M. Collazo, George S. Yap, Khuong Nguyen, Theresa A. Gregorio, Lynn S. Taylor, Bryn Eagleson, Lisa Secrest, Eileen A. Southon, Susan W. Reid, Lino Tessarollo, Mike Bray, Dan W. McVicar, Kristin L. Komschlies, Howard A. Young, Christine A. Biron, Alan Sher, and George F. Vande Woude PMCID: PMC15402 T cell receptor interactions with class I heavy-chain influence T cell selection Scott T. Kuhns, Michelle D. Tallquist, Aaron J. Johnson, Yanice Mendez-Fernandez, and Larry R. Pease PMCID: PMC15403 Prevention of passively transferred experimental autoimmune myasthenia gravis by a phage library-derived cyclic peptide Natarajan Venkatesh, Sin-Heyog Im, Moshe Balass, Sara Fuchs, and Ephraim Katchalski-Katzir PMCID: PMC15404 Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice Mélisande Richard, Richard K. Grencis, Neil E. Humphreys, Jean-Christophe Renauld, and Jacques Van Snick PMCID: PMC15405 Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family Hanzhong Li, Jian Chen, Arthur Huang, Jeremy Stinson, Sherry Heldens, Jessica Foster, Patrick Dowd, Austin L. Gurney, and William I. Wood PMCID: PMC15406 Medical Sciences Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor Yasuhito Shimizu, Yoko Nakatsuru, Masao Ichinose, Yoshihisa Takahashi, Haruki Kume, Junsei Mimura, Yoshiaki Fujii-Kuriyama, and Takatoshi Ishikawa PMCID: PMC15407 Drug target validation: Lethal infection blocked by inducible peptide Jianshi Tao, Philip Wendler, Gene Connelly, Audrey Lim, Jiansu Zhang, Megan King, Tongchuan Li, Jared A. Silverman, Paul R. Schimmel, and Francis P. Tally PMCID: PMC15408 From the Cover:
Targeted disruption of hormone-sensitive lipase results in male
sterility and adipocyte hypertrophy, but not in obesity Jun-ichi Osuga, Shun Ishibashi, Teruaki Oka, Hiroaki Yagyu, Ryuichi Tozawa, Akihisa Fujimoto, Futoshi Shionoiri, Naoya Yahagi, Frederic B. Kraemer, Osamu Tsutsumi, and Nobuhiro Yamada PMCID: PMC15409 Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure Michael I. Miyamoto, Federica del Monte, Ulrich Schmidt, Thomas S. DiSalvo, Zhao Bin Kang, Takashi Matsui, J. Luis Guerrero, Judith K. Gwathmey, Anthony Rosenzweig, and Roger J. Hajjar PMCID: PMC15410 Intestinal trefoil factor confers colonic epithelial resistance to apoptosis D. R. Taupin, K. Kinoshita, and D. K. Podolsky PMCID: PMC15411 Functional deletion of the CCR5 receptor by intracellular immunization produces cells that are refractory to CCR5-dependent HIV-1 infection and cell fusion Peter Steinberger, Jennifer Andris-Widhopf, Bernd Bühler, Bruce E. Torbett, and Carlos F. Barbas, III PMCID: PMC15412 Cationic microparticles: A potent delivery system for DNA vaccines Manmohan Singh, Maylene Briones, Gary Ott, and Derek O'Hagan PMCID: PMC15413 ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport Jochen Klucken, Christa Büchler, Evelyn Orsó, Wolfgang E. Kaminski, Mustafa Porsch-Özcürümez, Gerhard Liebisch, Michael Kapinsky, Wendy Diederich, Wolfgang Drobnik, Michael Dean, Rando Allikmets, and Gerd Schmitz PMCID: PMC15414 An in vivo approach showing the chemotactic activity of leukotriene B4 in acute renal ischemic-reperfusion injury Eisei Noiri, Takehiko Yokomizo, Akihide Nakao, Takashi Izumi, Toshiro Fujita, Satoshi Kimura, and Takao Shimizu PMCID: PMC15415 Stability of cytotoxic luteinizing hormone-releasing hormone conjugate (AN-152) containing doxorubicin 14-O-hemiglutarate in mouse and human serum in vitro: Implications for the design of preclinical studies Attila Nagy, Artur Plonowski, and Andrew V. Schally PMCID: PMC15416 Extracellular protein kinase A as a cancer biomarker: Its expression by tumor cells and reversal by a myristate-lacking Cα and RIIβ subunit overexpression Yee Sook Cho, Yun Gyu Park, Youl Nam Lee, Meyoung-Kon Kim, Susan Bates, Langzhu Tan, and Yoon S. Cho-Chung PMCID: PMC15417 Aortic wall damage in mice unable to synthesize ascorbic acid Nobuyo Maeda, Hiroyuki Hagihara, Yukiko Nakata, Sylvia Hiller, Jennifer Wilder, and Robert Reddick PMCID: PMC15418 Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization Hui Wang, Michelle N. Griffiths, Dennis R. Burton, and Peter Ghazal PMCID: PMC15419 Microbiology Specific chromosome 1 breaks induced by human cytomegalovirus Elizabeth A. Fortunato, Marie L. Dell'Aquila, and Deborah H. Spector PMCID: PMC15420 Genetic analysis of a bacterial genetic exchange element: The
gene transfer agent of
Rhodobacter capsulatus Andrew S. Lang and J. T. Beatty PMCID: PMC15421 Neurobiology Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy Min Liu, Samuel J. Pleasure, Abigail E. Collins, Jeffrey L. Noebels, Francesco J. Naya, Ming-Jer Tsai, and Daniel H. Lowenstein PMCID: PMC15422 ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation Carrolee Barlow, Catherine Ribaut-Barassin, Theresa A. Zwingman, Amber J. Pope, Kevin D. Brown, Jennie W. Owens, Denise Larson, Elizabeth A. Harrington, Anne-Marie Haeberle, Jean Mariani, Michael Eckhaus, Karl Herrup, Yannick Bailly, and Anthony Wynshaw-Boris PMCID: PMC15423 Direct evidence for local oscillatory current sources and intracortical phase gradients in turtle visual cortex James C. Prechtl, Theodore H. Bullock, and David Kleinfeld PMCID: PMC15424 Kinetics of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse of the mouse Tobias Moser and Dirk Beutner PMCID: PMC15425 Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system Miriam J. Chong, Michael R. Murray, Eric C. Gosink, Helen R. C. Russell, Anu Srinivasan, Manuela Kapsetaki, Stanley J. Korsmeyer, and Peter J. McKinnon PMCID: PMC15426 Constraining the subunit order of rod cyclic nucleotide-gated channels reveals a diagonal arrangement of like subunits Yejun He, MariaLuisa Ruiz, and Jeffrey W. Karpen PMCID: PMC15427 Dynamics of dendritic calcium transients evoked by quantal release at excitatory hippocampal synapses Venkatesh N. Murthy, Terrence J. Sejnowski, and Charles F. Stevens PMCID: PMC15428 Effect of G protein heterotrimer composition on coupling of neurotransmitter receptors to N-type Ca2+ channel modulation in sympathetic neurons Seong-Woo Jeong and Stephen R. Ikeda PMCID: PMC15429 Temporal dynamics of cortical representation for action N. Nishitani and R. Hari PMCID: PMC15430 Theta oscillations index human hippocampal activation during a working memory task C. D. Tesche and J. Karhu PMCID: PMC15431 Pharmacology Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors Amit S. Kalgutkar, Brenda C. Crews, Scott W. Rowlinson, Alan B. Marnett, Kevin R. Kozak, Rory P. Remmel, and Lawrence J. Marnett PMCID: PMC15432 Physiology Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling Pierre Paradis, Nassim Dali-Youcef, François W. Paradis, Gaétan Thibault, and Mona Nemer PMCID: PMC15433 Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase S.-L. Shyng, A. Barbieri, A. Gumusboga, C. Cukras, L. Pike, J. N. Davis, P. D. Stahl, and C. G. Nichols PMCID: PMC15434 Plant Biology Plant organ size control: AINTEGUMENTA regulates growth and cell numbers during organogenesis Yukiko Mizukami and Robert L. Fischer PMCID: PMC15435 An Arabidopsis histone H2A mutant is deficient in Agrobacterium T-DNA integration Kirankumar S. Mysore, Jaesung Nam, and Stanton B. Gelvin PMCID: PMC15436 |
