| | This journal provides immediate access to some articles. Commentaries T4 replication: What does “processivity” really mean? Catherine M. Joyce Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8255–8256. Published online 2004 May 24. doi: 10.1073/pnas.0402850101.PMCID: PMC420379 Environmental signatures in proteome properties Luciano Brocchieri Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8257–8258. Published online 2004 May 24. doi: 10.1073/pnas.0402797101.PMCID: PMC420380 Biography INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Pietro De Camilli Liza Bundesen Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8259–8261. Published online 2004 May 24. doi: 10.1073/pnas.0403132101.PMCID: PMC420381 Physical Sciences Chemistry Dynamers: Polyacylhydrazone reversible covalent polymers, component exchange, and constitutional diversity Williams G. Skene and Jean-Marie P. Lehn Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8270–8275. Published online 2004 May 18. doi: 10.1073/pnas.0401885101.PMCID: PMC420383 Molecular sorting by stochastic resonance Damien Alcor, Vincent Croquette, Ludovic Jullien, and Annie Lemarchand Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8276–8280. Published online 2004 May 20. doi: 10.1073/pnas.0400663101.PMCID: PMC420384 Geology Magnetic tests for magnetosome chains in Martian meteorite ALH84001 Benjamin P. Weiss, Soon Sam Kim, Joseph L. Kirschvink, Robert E. Kopp, Mohan Sankaran, Atsuko Kobayashi, and Arash Komeili Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8281–8284. Published online 2004 May 20. doi: 10.1073/pnas.0402292101.PMCID: PMC420385 Biological Sciences Applied Biological Sciences Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria Miro Smriga, Shibani Ghosh, Youssef Mouneimne, Peter L. Pellett, and Nevin S. Scrimshaw Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8285–8288. Published online 2004 May 24. doi: 10.1073/pnas.0402550101.PMCID: PMC420386 Biochemistry From the Cover: The dynamic processivity of the T4 DNA polymerase during replication Jingsong Yang, Zhihao Zhuang, Rosa Maria Roccasecca, Michael A. Trakselis, and Stephen J. Benkovic Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8289–8294. Published online 2004 May 17. doi: 10.1073/pnas.0402625101.PMCID: PMC420387 Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis Nayden Koon, Christopher J. Squire, and Edward N. Baker Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8295–8300. Published online 2004 May 24. doi: 10.1073/pnas.0400820101.PMCID: PMC420388 Structural basis for the attachment of a paramyxoviral polymerase to its template Richard L. Kingston, Damon J. Hamel, Leslie S. Gay, Frederick W. Dahlquist, and Brian W. Matthews Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8301–8306. Published online 2004 May 24. doi: 10.1073/pnas.0402690101.PMCID: PMC420389 Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III Haihong Wu, Anthony Henras, Guillaume Chanfreau, and Juli Feigon Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8307–8312. Published online 2004 May 18. doi: 10.1073/pnas.0402627101.PMCID: PMC420390 Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells Masanari Matsumoto, Takashi Miki, Tadao Shibasaki, Miho Kawaguchi, Hidehiro Shinozaki, Junko Nio, Atsunori Saraya, Haruhiko Koseki, Masaru Miyazaki, Toshihiko Iwanaga, and Susumu Seino Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8313–8318. Published online 2004 May 24. doi: 10.1073/pnas.0306709101.PMCID: PMC420391 Involvement of Per–Arnt–Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose Gabriela da Silva Xavier, Jared Rutter, and Guy A. Rutter Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8319–8324. Published online 2004 May 17. doi: 10.1073/pnas.0307737101.PMCID: PMC420392 A high-affinity interaction between NusA and the rrn nut site in Mycobacterium tuberculosis Kristine B. Arnvig, S. Pennell, B. Gopal, and M. J. Colston Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8325–8330. Published online 2004 May 24. doi: 10.1073/pnas.0401287101.PMCID: PMC420393 Biophysics From the Cover: Structure of membrane-bound α-synuclein studied by site-directed spin labeling Christine C. Jao, Ani Der-Sarkissian, Jeannie Chen, and Ralf Langen Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8331–8336. Published online 2004 May 20. doi: 10.1073/pnas.0400553101.PMCID: PMC420394 Predicting indirect readout effects in protein–DNA interactions Yongli Zhang, Zhiqun Xi, Rashmi S. Hegde, Zippora Shakked, and Donald M. Crothers Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8337–8341. Published online 2004 May 17. doi: 10.1073/pnas.0402319101.PMCID: PMC420395 Evidence for assembly of prions with left-handed β-helices into trimers Cédric Govaerts, Holger Wille, Stanley B. Prusiner, and Fred E. Cohen Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8342–8347. Published online 2004 May 21. doi: 10.1073/pnas.0402254101.PMCID: PMC420396 3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex Beili Wu, Pengyun Li, Yiwei Liu, Zhiyong Lou, Yi Ding, Cuiling Shu, Sheng Ye, Mark Bartlam, Beifen Shen, and Zihe Rao Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8348–8353. Published online 2004 May 24. doi: 10.1073/pnas.0305969101.PMCID: PMC420397 Simulation, experiment, and evolution: Understanding nucleation in protein S6 folding Isaac A. Hubner, Mikael Oliveberg, and Eugene I. Shakhnovich Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8354–8359. Published online 2004 May 18. doi: 10.1073/pnas.0401672101.PMCID: PMC420398 Cell Biology INAUGURAL ARTICLE by a Recently Elected Academy Member: Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: Insights from vesicle recycling in nerve terminals Markus R. Wenk and Pietro De Camilli Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8262–8269. Published online 2004 May 14. doi: 10.1073/pnas.0401874101.PMCID: PMC420382 Bipotential mouse embryonic liver stem cell lines contribute to liver regeneration and differentiate as bile ducts and hepatocytes Hélène Strick-Marchand, Serban Morosan, Pierre Charneau, Dina Kremsdorf, and Mary C. Weiss Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8360–8365. Published online 2004 May 20. doi: 10.1073/pnas.0401092101.PMCID: PMC420399 XLαs, the extra-long form of the α-subunit of the Gs G protein, is significantly longer than suspected, and so is its companion Alex Joel Abramowitz, Dagoberto Grenet, Mariel Birnbaumer, Hector N. Torres, and Lutz Birnbaumer Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8366–8371. Published online 2004 May 17. doi: 10.1073/pnas.0308758101.PMCID: PMC420400 Trafficking of ODV-E66 is mediated via a sorting motif and other viral proteins: Facilitated trafficking to the inner nuclear membrane Sharon C. Braunagel, Shawn T. Williamson, Suraj Saksena, Zhenping Zhong, William K. Russell, David H. Russell, and Max D. Summers Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8372–8377. Published online 2004 May 18. doi: 10.1073/pnas.0402727101.PMCID: PMC420401 Developmental Biology phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development Haiwei Pi, Shao-Kuei Huang, Chiou-Yang Tang, Y. Henry Sun, and Cheng-Ting Chien Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8378–8383. Published online 2004 May 17. doi: 10.1073/pnas.0306010101.PMCID: PMC420402 Molecular diversity of astrocytes with implications for neurological disorders Robert M. Bachoo, Ryung S. Kim, Keith L. Ligon, Elizabeth A. Maher, Cameron Brennan, Nathan Billings, Suzanne Chan, Cheng Li, David H. Rowitch, Wing H. Wong, and Ronald A. DePinho Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8384–8389. Published online 2004 May 21. doi: 10.1073/pnas.0402140101.PMCID: PMC420403 Evolution From the Cover: Global analysis of predicted proteomes: Functional adaptation of physical properties Christopher G. Knight, Rees Kassen, Holger Hebestreit, and Paul B. Rainey Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8390–8395. Published online 2004 May 18. doi: 10.1073/pnas.0307270101.PMCID: PMC420404 The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus Rafael Sanjuán, Andrés Moya, and Santiago F. Elena Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8396–8401. Published online 2004 May 24. doi: 10.1073/pnas.0400146101.PMCID: PMC420405 Genetics Deletion of the Parkin coregulated gene causes male sterility in the quakingviable mouse mutant Diego Lorenzetti, Colin E. Bishop, and Monica J. Justice Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8402–8407. Published online 2004 May 17. doi: 10.1073/pnas.0401832101.PMCID: PMC420406 From the Cover: Differential plague-transmission dynamics determine Yersinia pestis population genetic structure on local, regional, and global scales Jessica M. Girard, David M. Wagner, Amy J. Vogler, Christine Keys, Christopher J. Allender, Lee C. Drickamer, and Paul Keim Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8408–8413. Published online 2004 May 20. doi: 10.1073/pnas.0401561101.PMCID: PMC420407 Programmable cells: Interfacing natural and engineered gene networks Hideki Kobayashi, Mads Kærn, Michihiro Araki, Kristy Chung, Timothy S. Gardner, Charles R. Cantor, and James J. Collins Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8414–8419. Published online 2004 May 24. doi: 10.1073/pnas.0402940101.PMCID: PMC420408 Immunology Cytokine detection by antibody-based proximity ligation Mats Gullberg, Sigrún M. Gústafsdóttir, Edith Schallmeiner, Jonas Jarvius, Mattias Bjarnegård, Christer Betsholtz, Ulf Landegren, and Simon Fredriksson Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8420–8424. Published online 2004 May 21. doi: 10.1073/pnas.0400552101.PMCID: PMC420409 Medical Sciences Deletion of macrophage-inflammatory protein 1α retards neurodegeneration in Sandhoff disease mice Yun-Ping Wu and Richard L. Proia Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8425–8430. Published online 2004 May 20. doi: 10.1073/pnas.0400625101.PMCID: PMC420410 Integrated modeling of clinical and gene expression information for personalized prediction of disease outcomes Jennifer Pittman, Erich Huang, Holly Dressman, Cheng-Fang Horng, Skye H. Cheng, Mei-Hua Tsou, Chii-Ming Chen, Andrea Bild, Edwin S. Iversen, Andrew T. Huang, Joseph R. Nevins, and Mike West Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8431–8436. Published online 2004 May 19. doi: 10.1073/pnas.0401736101.PMCID: PMC420411 Nuclear receptor corepressor RIP140 regulates fat accumulation Göran Leonardsson, Jenny H. Steel, Mark Christian, Victoria Pocock, Stuart Milligan, Jimmy Bell, Po-Wah So, Gema Medina-Gomez, Antonio Vidal-Puig, Roger White, and Malcolm G. Parker Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8437–8442. Published online 2004 May 20. doi: 10.1073/pnas.0401013101.PMCID: PMC420412 Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice Shinobu Tsuzuki, Masao Seto, Mel Greaves, and Tariq Enver Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8443–8448. Published online 2004 May 20. doi: 10.1073/pnas.0402063101.PMCID: PMC420413 Microbiology Magnetic tests for magnetosome chains in Martian meteorite ALH84001 Benjamin P. Weiss, Soon Sam Kim, Joseph L. Kirschvink, Robert E. Kopp, Mohan Sankaran, Atsuko Kobayashi, and Arash Komeili Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8281–8284. Published online 2004 May 20. doi: 10.1073/pnas.0402292101.PMCID: PMC420385 Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax Alex R. Hoffmaster, Jacques Ravel, David A. Rasko, Gail D. Chapman, Michael D. Chute, Chung K. Marston, Barun K. De, Claudio T. Sacchi, Collette Fitzgerald, Leonard W. Mayer, Martin C. J. Maiden, Fergus G. Priest, Margaret Barker, Lingxia Jiang, Regina Z. Cer, Jennifer Rilstone, Scott N. Peterson, Robbin S. Weyant, Darrell R. Galloway, Timothy D. Read, Tanja Popovic, and Claire M. Fraser Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8449–8454. Published online 2004 May 21. doi: 10.1073/pnas.0402414101.PMCID: PMC420414 Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides Berend Jan Bosch, Byron E. E. Martina, Ruurd van der Zee, Jean Lepault, Bert Jan Haijema, Cees Versluis, Albert J. R. Heck, Raoul de Groot, Albert D. M. E. Osterhaus, and Peter J. M. Rottier Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8455–8460. Published online 2004 May 18. doi: 10.1073/pnas.0400576101.PMCID: PMC420415 Neuroscience Functional photoreceptor loss revealed with adaptive optics: An alternate cause of color blindness Joseph Carroll, Maureen Neitz, Heidi Hofer, Jay Neitz, and David R. Williams Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8461–8466. Published online 2004 May 17. doi: 10.1073/pnas.0401440101.PMCID: PMC420416 NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex Mark E. Jackson, Houman Homayoun, and Bita Moghaddam Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8467–8472. Published online 2004 May 24. doi: 10.1073/pnas.0308455101.PMCID: PMC420417 Voluntary exercise increases axonal regeneration from sensory neurons Raffaella Molteni, Jun-Qi Zheng, Zhe Ying, Fernando Gómez-Pinilla, and Jeffery L. Twiss Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8473–8478. Published online 2004 May 24. doi: 10.1073/pnas.0401443101.PMCID: PMC420418 Completion of neuronal migration regulated by loss of Ca2+ transients Tatsuro Kumada and Hitoshi Komuro Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8479–8484. Published online 2004 May 18. doi: 10.1073/pnas.0401000101.PMCID: PMC420419 Gene knockout of glycine transporter 1: Characterization of the behavioral phenotype Guochuan Tsai, Rebecca J. Ralph-Williams, Marzia Martina, Richard Bergeron, Joanne Berger-Sweeney, Kevin S. Dunham, Zhichun Jiang, S. Barak Caine, and Joseph T. Coyle Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8485–8490. Published online 2004 May 24. doi: 10.1073/pnas.0402662101.PMCID: PMC420420 From the Cover: Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress Pranab K. Mukherjee, Victor L. Marcheselli, Charles N. Serhan, and Nicolas G. Bazan Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8491–8496. Published online 2004 May 19. doi: 10.1073/pnas.0402531101.PMCID: PMC420421 Pharmacology Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties Ennio Ongini, Francesco Impagnatiello, Albino Bonazzi, Massimiliano Guzzetta, Mirco Govoni, Angela Monopoli, Piero Del Soldato, and Louis J. Ignarro Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8497–8502. doi: 10.1073/pnas.0401996101.PMCID: PMC420422 Physiology Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation Pauline M. Anton, Jerome Gay, Andreas Mykoniatis, Amy Pan, Michael O'Brien, Daniel Brown, Katia Karalis, and Charalabos Pothoulakis Proc Natl Acad Sci U S A. 2004 June 1; 101(22): 8503–8508. Published online 2004 May 24. doi: 10.1073/pnas.0402693101.PMCID: PMC420423 |