Ph.D. student-University of Massachusetts,
Amherst
Education
M. S. University of Arkansas, Pine Bluff, 2000
B. S. University of Massachusetts, Amherst, 1997
Research Interests
Primary scientific interests involve infectious and non-infectious diseases
of fishes, the pathology/ immune responses they elicit and the influence
of hormones on immune function. Immunologic and endocrine parameters are
often affected by certain environmental contaminants and thus serve as
sensitive indicators of biological modulation. Quantification and comparison
of such parameters from fish in impacted systems to fishes in biologically
relevant reference ecosystems offers a powerful, sensitive approach for
assessing ecosystem health/ change. Analysis of data garnered from biological
indicators of environmental "stress" and epidemiologic measures
can then be used to develop indices and predictive health models for environmental
monitoring. My research is conducted at both the Conte Anadromous Fish
Research Center and the National Fish Health Research Laboratory in Leetown,
WV.
Current projects include:
1) Assessing ecosystem health in the Ashtabula River, Ohio and Chesapeake
Bay watershed using a suite of sensitive immunologic, toxicologic, endocrine
and reproduction associated biomarkers. This project is a collaborative
effort by numerous federal and state agencies.
2) Examining the effects of environmental contaminants on normal endocrine
and immunologic function in Atlantic salmon, largemouth bass, brown bullheads
and white perch. Histological assessment using image analysis technology
is also utilized.
3) Production of monoclonal antibodies to detect largemouth bass immunoglobulins
for applied immunoassays.
4) Developing novel immunoassays and laser scanning cytometric (LSC) methods
for assessing fish health.
5) Investigating the immunomodulatory effects of hormones and putative
endocrine disruptors on fish leukocytes.
Publications
L Iwanowicz, C Densmore and C Ottinger (2004) Calcein AM released-based
cytotoxic cell assay for fish leucocytes. Fish & Shellfish Immunology.
In press.
M. McIntire, L R Iwanowicz, and A E Goodwin (2004) Molecular,
physical and clinical evidence that Golden Shiner Virus (GSV) and Grass
Carp Reovirus (GCRV) are variants of the same virus. Journal of Aquatic
Animal Health. In press
L R Iwanowicz and A E Goodwin (2002) Characterization
of a new bacilliform fathead minnow rhabdovirus that produces syncytia
in tissue culture. Archives of Virology 147: 889 - 916.
Christine L. Densmore, Christopher A. Ottinger, Vicki
Blazer and Luke R. Iwanowicz (2002). Immunomodulation and disease resistance
in Myxobolus cerebralis infected rainbow trout. Proceedings of
the 8th Annual Whirling Disease Symposium.
L R Iwanowicz, A E Goodwin and J Harshbarger (2001) Embryonal
rhabdomyosarcoma of the giant gourami, Colisa fasciata (Bloch &
Schneider). Journal of Fish Diseases 24:177-179.
L R Iwanowicz, A E Goodwin and N Heil (2000) A small RNA
virus isolated from apparently healthy wild sandbar shiners, Notropis
scepticus. Journal of Fish Diseases 23: 349-352.
Submitted
L Iwanowicz, L Brown, B Eltz, F. Juanes and J. Murt (2003) Book Review:
In a Perfect Ocean: The state of our fisheries and ecosystems in the North
Atlantic Ocean. Fisheries Review.
Christine Densmore, Christopher Ottinger, Vicki Blazer,
Luke Iwanowicz and Dave Smith (2003). Immunomodulation and disease resistance
in post-yearling rainbow trout (Oncorynchus mykiss) infected with
Myxobolus cerebralis, the causative agent of whirling disease.
Journal of Aquatic Animal Health
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