Biology Direct considers original research articles, hypotheses, comments, discovery notes and reviews in selected subject areas, and will eventually cover the full spectrum of biology.

Subject areas already launched include:
- Genomics, Bioinformatics and Systems Biology - Edited by Eugene Koonin, Laura Landweber, & David Lipman
- Immunology - Edited by Neil S Greenspan & David R Kaplan
- Mathematical Biology - Edited by Marek Kimmel.

Submit your manuscript online.

In 2009, to commemorate the 200th anniversary of Charles Darwin's birth and the 150th anniversary of the publication of the "Origin of Species", Biology Direct plans to publish a thematic series dedicated to the current state of Evolutionary Biology, under the general heading "Evolutionary Biology 150 after the 'Origin': Is a post-modern synthesis in sight?" The series will consist of a number of critical reviews and discussion articles that will investigate and assess today's understanding of evolution at all levels, the fate of the legacy of Darwin and the Modern Synthesis, and the goals and prospects for the next half-century; original contributions with broad implications and extended discussion will be considered as well. Some of the contributions will be invited but proposals are welcome and should be emailed to Eugene Koonin.

The deadline for proposal submission is July 1, 2009.