What is essential tremor? (Back to Top)
Essential tremor is a disorder of the nervous system that causes involuntary, rhythmic shaking (tremor), especially in the hands. It involves tremor without any other signs or symptoms, and is distinguished from tremor that results from other disorders or known causes, such as tremors seen with Parkinson disease or head trauma.[1] Essential tremor (sometimes called benign essential tremor) is the most common of the more than 20 types of tremor.[2] Essential tremor is a complex disorder. Several genes are believed to help determine an individual's risk of developing this condition. Environmental factors may also be involved.[1] In mild cases, treatment may not be necessary. In cases where symptoms interfere with daily living, medications may help to relieve symptoms.[3]
What causes essential tremor? (Back to Top)
In other studies, the gene HS1BP3 has also been associated with essential tremor. The HS1BP3 gene provides instructions for making a protein called hematopoietic-specific protein 1 binding protein 3. This protein is believed to help regulate chemical signaling in the brain region involved in coordinating movements (the cerebellum) and in specialized nerve cells in the brain and spinal cord that control the muscles (motor neurons). An HS1BP3 variant has been identified in some families affected by essential tremor, but it has also been found in unaffected people. It is unknown what relationship, if any, this genetic change may have to the signs and symptoms of this condition.[1]
Can the symptoms of essential tremor interfere with the activities of daily life? (Back to Top)
The symptoms of essential tremor may be aggravated by emotional stress, fever, fatigue, hunger (low blood sugar), caffeine, cigarette smoking, or extremes of temperature.[1][2]
How might essential tremor be managed? (Back to Top)
These drugs can have significant side effects.[3]Eliminating tremor "triggers" such as caffeine and other stimulants from the diet is often recommended. Physical therapy may help to reduce tremor and improve coordination and muscle control for some patients.[2] More details about the management of essential tremor can be accessed through the following web links:http://www.mayoclinic.com/print/essential-tremor/DS00367/METHOD=print&DSECTION=all http://emedicine.medscape.com/article/1150290-treatmenthttp://www.wemove.org/et/et_tre.html
We recommend that you discuss this information and your concerns with a genetics professional. The following online resources can help you find a genetics professional in your community:
* GeneClinics - A searchable directory of US and international genetics and prenatal diagnosis clinics. To locate genetics clinics in the United States, go to the following link and click on 'Clinic Directory' to find a genetic service close to you. * ResourceLink - A database of genetics counseling services, searchable by location, name, institution, type of practice, or specialty. Hosted by the National Society of Genetic Counselors.