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Abstract
Grant Number: 5R03LM008281-02 Project Title: Analytic Technique for Single-Subject Designs
PI Information: Name Title JANOSKY, JANINE E. janos1je@cmich.edu Abstract: DESCRIPTION (provided by applicant): This proposal involves the development of research methodology and the accompanying technology. A research design that is being used more frequently in practice-based healthcare research is the single subject research design (i.e., clinical trial of N=I). However, the statistical assessment of clinical effectiveness of the intervention when using this design is controversial. The data analytic approaches most often chosen for this assessment have not been shown to be valid. The use of a nonparamedic smoother has been validated as a descriptive tool, but further development and testing needs to be completed for an inferential tool. This proposal involves the development and validation of a general data analytic strategy for the statistical assessment of data from a single-subject research design. Of focus is the A-B research design. It is proposed that such a data analytic strategy might combine a nonparamedic smoother with a randomization test, thus resulting in a descriptive and inferential means of examination and the determination of effectiveness of the intervention for the assessment of practice-based single-subject designs. The development of the methodology, the empirical investigation of this methodology, the application to ongoing medical research, and the needed technology for this design is proposed. It is anticipated that, once developed, this methodology and technology will be available to the health sciences research community.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
analytical method, data collection methodology /evaluation, experimental design, method development
computer data analysis, health science research analysis /evaluation, information dissemination, statistics /biometry
clinical research, computer simulation
Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH 350 THACKERAY HALL PITTSBURGH, PA 15260 Fiscal Year: 2006 Department: FAMILY MEDICINE Project Start: 15-DEC-2004 Project End: 14-JUN-2007 ICD: NATIONAL LIBRARY OF MEDICINE IRG: ZLM1