Project Title:

Non-Invasive Bone Strength Measurement by a Mechanical-Response Tissue Analyzer

12.10-4164G
900470
Non-Invasive Bone Strength Measurement by a Mechanical-Response Tissue Analyzer 

Abstract:

Bone weakening is a concern for astronauts who now exercise in flight to prevent
loss of bone in the legs and fracture on landing. This project will design an instrument
for direct, non-invasive measurement of bone strength. The innovation is the methodology
acquired by this company from a University and the design of an instrument that will
provide accurate, reproducible measurements of bone stiffness, a component of strength.
The long bones of the lower extremities of humans and larger species of animals qualifying
for flight projects are the targets of analysis by this instrument. It delivers a
low frequency vibration and detects the response. Current methods for evaluating
the strength of bone in vivo depend primarily on measures of the mineral content
of bone by instruments that contain a radio-active source. A device to monitor the
effects of exercise on bone strength that avoids exposure to radiation is needed
for space flight and would also have application in monitoring patients with fragile
bones or individuals engaged in sports or fitness programs. The objective of Phase
I is to design the mechanical components and data acquisition system into a single
simple system for operation and use in clinical and animal studies. The objective
of Phase II is to validate the instrument by animal and human tests and correlate
with other tests.
The device would be used in research centers and in health and fitness facilities
as a routine means of monitoring the bone strengthening effects of exercise, diet
and other factors.
bone, strength, exerciser, mineral, biomechanics