Jacob Selhub
Human Nutrition Research Center on Aging
Nutrition Scientist
Phone: (617) 556-3191
Fax: (617) 556-3344
Room 813 USDA-ARS-HNRCA
711 WASHINGTON STREET BOSTON, MA, 02111
Troen, A.M., Shea-Budgell, M., Shukitt Hale, B., Smith, D., Selhub, J., Rosenberg, I. 2008. B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proceedings of the National Academy of Sciences. 105(34):12474-12479.
Mason, J.B., Cole, B.F., Baron, J.A., Kim, Y., Refsum, H., Selhub, J., Smith, A. 2008. Folic acid fortification and cancer risk: plea for objective evaluation of the evidence. Lancet. 371: 1335-1336.
Mclean, R.R., Jacques, P., Selhub, J., Fredman, L., Tucker, K., Samelson, E.J., Kiel, D.P., Cupples, L.A., Hannan, M.T. 2008. Plasma B vitamins, homocysteine and their relation with bone loss and hip fracture in elderly men and women. Journal of Clinical Endocrinology and Metabolism. 93(6):2206-2212.
Morris, M.S., Jacques, P., Rosenberg, I., Selhub, J. 2008. Will Increasing Folic Acid in Fortified Grain Products Further Reduce Neural Tube Defects without Causing Harm?: Consideration of the Evidence. Pediatric Research. 63(4):450.
Morris, M.S., Jacques, P., Selhub, J. 2008. Response to Quinlivan: Post-fortification, folate intake in vitamin B12 deficiency is positively related to homocysteine and methylmalonic acid. Proceedings of the National Academy of Sciences. 105(5):E8.
Morris, M.S., Picciano, M.F., Jacques, P., Selhub, J. 2008. Plasma Pyridoxal 5'-phosphate (PLP) in the United States population: the National Health and Nutrition Examination Survey, 2003-2004. American Journal of Clinical Nutrition. 87(5):1446-1454.
Kalmbach, R., Choumenkovitch, S., Jacques, P., D'Agostino, R.B., Troen, A., Selhub, J. 2008. Relationship between the 19 base pair deletion polymorphism in DHFR and unmetabolized folic and in plasma and RBC folate. Federation of American Societies for Experimental Biology Journal. 22:296.4.
Hamer, D., Sempertegui, F., Estrella, B., Tucker, K., Rodriguez, A., Egas, J., Dallal, G., Selhub, J., Meydani, S. 2008. Nutritional and Immunological Status and Burden of Infection in Elderly Ecuadorian. Experimental Biology. Abstract No. 450.5.
Selhub, J., Morris, M.S., Jacques, P. 2007. In vitamin B12 deficiency, higher serum folate is assoicated with increased total homocysteine (tHcy) and methlmalonic acid (MMA) concentrations. Proceedings of the National Academy of Sciences. 104(50):19995-20000.
Lin, J., Manson, J.E., Selhub, J., Buring, J.E., Zhang, S.M. 2007. Plasma Cysteinylglycine Levels and Breast Cancer Risk in Women. Cancer Research. 67:11123-11127. doi:10.1158/0008-5472.
Lin, J., Lee, I., Cook, N.R., Selhub, J., Manson, J.E., Buring, J.E., Zhang, S.M. 2008. Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women. American Journal of Clinical Nutrition. 87(3):734-43.
Mason, J.B., Dickstein, A., Jacques, P., Haggarty, P., Selhub, J., Dallal, G., Rosenberg, I. 2007. A temporal association between folic acid fortification and a rise in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiology Biomarkers and Prevention. 16:1.
Dietrich, M., Jacques, P., Polak, J., Pencina, M., Evans, J., Selhub, J., Vasan, R., D'Agostino, R. 2006. Plasma Homocysteine and Carotid Artery Intima-Media Thickness: Site-Specific Associations in the Framingham Offspring cohort. Federation of American Societies of Experimental Biology. Abstract no. 660.9.
Poo-Prieto, R., Haytowitz, D.B., Holden, J.M., Rogers, G., Choumenkovitch, S.F., Jacques, P.F., Selhub, J. 2006. Use of the affinity/HPLC method for quantitative estimation of folic acid enriched cereal grain products. Journal of Nutrition. 136:3079-3083.
Wang, T.J., Gona, P., Larson, M.G., Toffler, G.H., Levy, D., Newton-Cheh, C., Jacques, P., Rifai, N., Selhub, J., Robins, S.J., Benjamin, E.J., D'Agostiono, R.B., Vasan, R.S. 2006. Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death. New England Journal of Medicine. 355(25): 2631-9.
Morris, M.S., Jacques, P., Rosenberg, I., Selhub, J. 2007. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. American Journal of Clinical Nutrition. 85(1):193-200.
Cho, E., Zeisel, S.H., Jacques, P.F., Selhub, J., Dougherty, L., Colditz, G.A., Willett, W.C. 2006. Dietary Choline and Betanine Assessed by Food-Frequency Questionnaire in Relation to Plasma Total Homocysteine Concentration in the Framingham Offspring Study. American Journal of Clinical Nutrition. 83(4):905-911.
Scott, T.M., Peter, I., Tucker, K.L., Arsenault, L., Bergethon, P., Bhadelia, R., Buell, J., Collinsa, L., Dashe, J.F., Griffith, J., Hibberd, P., Leins, D., Liu, T., Ordovas, J.M., Patz, S., Price, L., Qui, W., Sarnak, M., Selhub, J., Smaldone, L., Wagner, C., Wang, L., Weiner, D., Yee, J., Rosenberg, I., Folstein, M. 2006. The nutrition, aging, and memory in elders (name) study: design and methods for a study of micronutrients and cognitive function in a homebound elderly population. International Journal or Geriatric Psychiatry. 21(6):519-28.
Selhub, J., Jacques, P., Dallal, G., Choumenkovitch, S., Rogers, G. 2008. The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status. Food and Nutrition Bulletin. 29(2)(Suppl):S67-S73.
Selhub, J., Rosenberg, I. 2008. Public health significance of supplementation or fortification of grain products with folic acid. Food and Nutrition Bulletin. 29(2)(Suppl):S173-S176.
Chiang, E.I., Selhub, J., Bagley, P.J., Dallal, G., Roubenoff, R. 2005. Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. Arthritis Research & Therapy. 133(4):1056-1059.
Friedman, A.N., Hunsicker, L.G., Selhub, J., Bostom, A.G. 2005. Total plasma homocysteine and arteriosclerotic outcomes in type 2 diabetes with nephropathy. Journal of the American Society of Nephrology. 16:3397-3402.
Elias, M.F., Sullivan, L.M., D'Agostino, R.B., Elias, P.K., Jacques, P.F., Selhub, J., Seshadri, S., Au, R., Beiser, A., Wolf, P.A. 2005. Homocysteine & Cognitive Performance in the Framingham Offspring Study: Age is Important. American Journal of Epidemiology. 162(7):644-653.
Spiegelstein, O., Gould, A., Wlodarczyk, B., Tsie, M., Lu, X., Troen, A., Selhub, J., Piedrahita, J.A., Salbaum, M.J., Kappen, C., Melny, S., James, J., Finnell, R.H. 2005. Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies. Journal of Toxicology and Applied Pharmacology. 203(1): 18-26.
Shai, I., Stampfer, M.J., Ma, J., Manson, J.E., Hankinson, S.E., Cannuscio, C., Selhub, J., Curthan, G., Rimm, E.B. 2004. Homocysteine as a risk factor for coronary heart diseases and its association with inflammatory biomarkers, lipids and dietary factors. Atherosclerosis. 177:375-381.
Mclean, R.R., Karasik, D., Selhub, J., Tucker, K., Ordovas, J.M., Russo, G.T., Cupples, A., Jacques, P., Kiel, D.P. 2004. A common polymorphism in the methylenetetrahydrofolate reductase (mthfr) gene is associated with quantitative ultrasound in those with low plasma folate. Journal of Bone and Mineral Research. 19:410-418.