| Bibliographic Citation | |
| Full Text |  521 K |
|---|---|
| Title | Tritium labelled nucleotides: Heterogeneous metal catalyzed exchange labelling of ATP with tritium gas |
| Creator/Author | Jaiswal, D.K. (Defence Research and Development Establishment, Gwalior (India)) ; Morimoto, H. ; Williams, P.G. ; Wemmer, D.E. (Lawrence Berkeley Lab., CA (United States)) |
| Publication Date | 1991 Sep 01 |
| OSTI Identifier | OSTI ID: 5989426; Legacy ID: DE92002268 |
| Report Number(s) | LBL-31313; CONF-9109287--3 |
| DOE Contract Number | AC03-76SF00098 |
| Other Number(s) | Other: ON: DE92002268; CNN: P41 RR01237 |
| Resource Type | Conference |
| Specific Type | Technical Report |
| Resource Relation | Conference: 4. international symposium on the synthesis and applications of isotopes and isotopically labeled compounds, Toronto (Canada), 3 Sep 1991 |
| Research Org | Lawrence Berkeley Lab., CA (United States) |
| Sponsoring Org | DOE; DOHHS; USDOE, Washington, DC (United States); Department of Health and Human Services, Washington, DC (United States) |
| Subject | 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; ATP; ISOTOPIC EXCHANGE; PALLADIUM; CATALYTIC EFFECTS; BARIUM SULFATES; HETEROGENEOUS CATALYSIS; NMR SPECTRA; PALLADIUM OXIDES; TRITIUM; ALKALINE EARTH METAL COMPOUNDS; BARIUM COMPOUNDS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CATALYSIS; CHALCOGENIDES; ELEMENTS; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; METALS; NUCLEI; NUCLEOTIDES; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; OXIDES; OXYGEN COMPOUNDS; PALLADIUM COMPOUNDS; PLATINUM METALS; RADIOISOTOPES; SPECTRA; SULFATES; SULFUR COMPOUNDS; TRANSITION ELEMENT COMPOUNDS; TRANSITION ELEMENTS; YEARS LIVING RADIOISOTOPES |
| Description/Abstract | Adenosine 5{prime} triphosphate (ATP) in aqueous solution has been labeled by exchange with tritium gas in the presence of palladium oxide catalyst. Comparison with our experiments using Pd/BaSO{sub 4} as the catalyst shows that we have obtained product with higher specific activity and improved chemical purity. {sup 3}H NMR spectroscopy of the tritiated ATP shows labelling in both the C-8 and C-2 positions, and the integral ratio of these positions was found to vary from 3:1 to 1:1 under different reaction conditions. 5 refs., 1 fig., 2 tabs. |
| Country of Publication | United States |
| Language | English |
| Format | Medium: ED; Size: Pages: (7 p) |
| Availability | OSTI; NTIS; INIS; GPO Dep. To purchase this media from NTIS, click here |
| System Entry Date | 2008 Feb 07 |
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Last Updated: 05/11/2009