Organic Geochemistry Research Laboratory

Liquid Chromatography/Mass Spectrometry (LC/MS)

Two Agilent 1100 Series liquid chromatography/mass spectrometers equipped with a diode array detector are in use for laboratory projects, methods development, and other special analyses.

LC/MS Analysis

LC/MS analyses performed by the Organic Geochemistry Research Laboratory are as follows. The laboratory code is indicated in parentheses after the method description.

• Acetamide Parents and Degradation Products (LCPD)
• Triazine and Phenylurea Parents and Degradation products (LCEA)
• Chlorothalonil and Degradation Products (LCCD)
• Isoxaflutole and Degradation Products (LCIX)

Selected LC/MS References

1. Ferrer, Imma, Barcelo, Damia, Thurman, E.M., 2000, First LC/MS Determination of Cyanazine Amide, Cyanazine Acid, and Cyanazine in Groundwater Samples, Environmental Science and Technology, v. 34, no. 4, p. 714-718.

2. Lee, E.A., Kish, J.L., Zimmerman, L.R., and Thurman, E.M., 2001, Methods of analysis by the U.S. Geological Survey Organic Geochemistry Research Group--Update and additions to the determination of chloroacetanilide herbicide degradation compounds in water using high-performance liquid chromatography/mass spectrometry: U.S. Geological Survey Open-File Report 01-10, 17 p.

3. Lee, E.A., Strahan, A.P., and Thurman, E.M., 2002, Methods of Analysis by the U.S. Geological Survey Organic Geochemistry Research Group-Determination of Glyphosate, Aminomethylphosphonic Acid, and Glufosinate in Water Using Online Solid-Phase Extraction and High-Performance Liquid Chromatography/Mass Spectrometry: U.S. Geological Survey Open-File Report 01-454, 13p.

4. Lee, E.A., Strahan, A.P., and Thurman, E.M., 2002, Methods of Analysis by the U.S. Geological Survey Organic Geochemistry Research Group—Determination of Triazine and Phenylurea Herbicides and Their Degradation Products in Water Using Solid-Phase Extraction and Liquid Chromatography/Mass Spectrometry: U.S. Geological Survey Open-File Report 02-436, 19 p.

5. Lee, E.A., Zimmerman, L.R., Bhullar, B.S., and Thurman, E.M., 2002, Linker-Assisted Immunoassay and Liquid Chromatography/Mass Spectrometry for the Analysis of Glyphosate, Analytical Chemistry, v. 74, p. 4937-4943.

6. Lee, E.A. and Strahan, A.P., 2003, Methods of Analysis by the U.S. Geological Survey Organic Geochemistry Research Group—Determination of Acetamide Herbicides and Their Degradation products in Water Using Online Solid-Phase Extraction and High-Performance Liquid Chromatography/Mass Spectrometry: U.S. Geological Survey Open-File Report 03-173, 17 p.

7. Lin, C.H., Lerch, R.N., Thurman, E.M., Garrett, H.E., George, M.F., 2002, Determination of Isoxaflutole (Balance) and Its Metabolites in Water Using Solid Phase Extraction Followed by High-Performance Liquid Chromatography with Ultraviolet or Mass Spectrometry: J. Agric. Food Chem., v. 50, p. 5816-5824.

8. Lindsey, M.E., Meyer, M.T., and Thurman, E.M., 2001, Analysis of Trace levels of Sulfonamide and Tetracycline Antimicrobials in Groundwater and Surface Water using Solid-Phase Extraction and Liquid Chromatography/Mass Spectrometry, Analytical Chemistry, v. 74, p. 4640-4646.

9. Meyer, M.T., Bumgarner, J.E., Varns, J.L, Daughtridge, J.V., Thurman, E.M., and Hostetler, K.A., 2000, Use of Radioimmunoassay as a Screen for Antibiotics in Confined Animal Feeding Operations and Confirmation by Liquid Chromatography/Mass Spectrometry: The Science of the Total Environment, v. 248, p. 181-188.

10. Scribner, E.A., Orlando, J.L., Battaglin, W.A., Sandstrom, M.W., Kuivila, K.M., and Meyer, M.T., 2006, Results of Analyses of the Fungicide Chlorothalonil, Its Degradation Product, and Other Selected Pesticides at 22 Surface-Water Sites in Five Southern States, 2003-04: U.S. Geological Survey Open-File Report 2006-1207, 59 p.

11. SScribner, E.A., Meyer, M.T., and Kalkhoff, S.J., 2006, Occurrence of isoxaflutole, acetamide, and triazine herbicides and their degradation products in 10 Iowa Rivers draining to the Mississippi and Missouri Rivers, 2004: U.S. Geological Survey Scientific Investigations Report 2006-5169, 84 p.