Projects

USING THE GENOME TO UNDERSTAND IMMUNOGENETICS OF POULTRY Appropriated (D)   Accession Number: 412469

GENETIC AND BIOLOGICAL DETERMINANTS OF AVIAN TUMOR VIRUS SUSCEPTIBILITY Appropriated (D)   Accession Number: 411767

GENOMICS AND IMMUNOGENETICS OF NEOPLASTIC DISEASE OF POULTRY Memorandum of Understanding (M)   Accession Number: 408275

EPIGENETIC CHANGES AND CHICKEN MAREK'S DISEASE ETIOLOGY Reimbursable (R)   Accession Number: 413411

IDENTIFYING SINGLE NUCLEOTIDE POLYMORPHISMS CONFERRING MAREK'S DISEASE RESISTANCE Reimbursable (R)   Accession Number: 412579

IDENTIFY SINGLE NUCLEOTIDE POLYMORPHISMS CONFERRING MAREK'S DISEASE RESISTANCE IN CHICKENS Specific Cooperative Agreement (S)   Accession Number: 414642

Publications

Non-MHC genomic variation affecting Marek¿s disease resistance and vaccine protective efficiency - (Abstract)

Chang, S., Dunn, J.R., Heidari, M., Lee, L.F., Song, J., Dodgson, J., Ding, Z., Zhang, H. 2009. Non-MHC Genomic Variation Affecting Marek¿s Disease Resistance and Vaccine Protective Efficiency [abstract]. International Plant and Animal Genome XVII Conference, January 9-14, 2009, San Diego, California. p. 526.

Genome-wide assessment of worldwide chicken SNP genetic diversity indicates significant absence of rare alleles in commercial breeds - (Peer Reviewed Journal)

Muir, W.M., Wong, G., Zhang, Y., Wang, J., Groenen, M., Crooijmans, R., Megens, H., Zhang, H., Okimoto, R., Vereijken, A., Jungerius, A., Albers, G., Taylor Lawley, C., Delany, M.E., Maceachern, S.A., Cheng, H.H. 2008. Genome-wide assessment of worldwide chicken SNP genetic diversity indicates significant absence of rare alleles in commercial breeds. Proceedings of the National Academy of Sciences. 105(45):17312-17317.

Transcriptional profiling of candidate genes induced by Marek's disease virus during cytolytic and latency infections - (Abstract)

Lee, L.F., Chang, S., Zhang, H., Heidari, M. 2008. Transcriptional profiling of candidate genes induced by Marek's disease virus during cytolytic and latency infections. American Veterinary Medical Association Convention Notes. 145th AVMA Annual Convention, July 19-22, 2008, New Orleans, LA. 2008 CD-ROM.

An integrated epigenetic and genetic analysis of DNA methyltransferase genes (DNMTs) in tumor resistant and susceptible chicken lines - (Peer Reviewed Journal)

YU, Y., Zhang, H., Tian, F., Zhang, W., Fang, H., Song, J. 2008. An integrated epigenetic and genetic analysis of DNA methyltransferase genes (DNMTs) in tumor resistant and susceptible chicken lines. PLoS One. 3(7):1-13.

Inhibition of Marek's disease virus replication by retroviral vector-based RNA interference - (Peer Reviewed Journal)

Chen, M., Payne, W.S., Hunt, H.D., Zhang, H., Holmen, S.L., Dodgson, J.B. 2008. Inhibition of Marek's disease virus replication by retroviral vector-based RNA interference. Virology. 377:265-272.

Survey of endogenous virus and TVB* receptor status of commercial chicken stocks supplying specific-pathogen-free eggs - (Peer Reviewed Journal)

Hunt, Henry D., Fadly, Aly M., Silva, Robert F., Zhang, Huanmin. 2008. Survey of endogenous virus and TVB* receptor status of commercial chicken stocks supplying specific-pathogen-free eggs. Avian Diseases. 52(3):433-440.

Development of an endogenous virus-free line of chickens susceptible to all subgroups of avian leukosis virus - (Peer Reviewed Journal)

Zhang, Huanmin, Bacon, Larry D., Fadly, Aly M. 2008. Development of an endogenous virus-free line of chickens susceptible to all subgroups of avian leukosis virus. Avian Diseases. 52(3):412-418.

Quantitative evaluation of DNA methylation patterns for ALVEs and TVB genes in a neoplastic disease susceptible and resistant chicken model - (Peer Reviewed Journal)

Yul, Y., Zhang, H.M., Tian, F., Bacon, L.D., Zhang, Y., Zhang, W., Song, J. 2008. Quantitative evaluation of DNA methylation patterns for ALVEs and TVB genes in a neoplastic disease susceptible and resistant chicken model. PLoS One. 3(3):e1731.

Marek's disease virus induces Th-2 activity during cytolytic infection - (Peer Reviewed Journal)

Heidari, M., Zhang, H.M., Sharif, S. 2008. Marek's disease virus induces Th-2 activity during cytolytic infection. Viral Immunology. 21(2):203-213.

Review of the initial validation and characterization of a 3K chicken SNP array - (Peer Reviewed Journal)

Muir, W.M., Wong, G.K., Zhang, Y., Wang, J., Groenen, M.A., Crooijmans, R.P., Megens, H.J., Zhang, H.M., McKay, J.C., McLeod, S., Okimoto, R., Fulton, J.E., Settar, P., O'Sullivan, N.P., Vereijken, A., Jungerius-Rattink, A., Albers, G.A., Lawley, C.T., Delany, M.E., Cheng, H.H. 2008. Review of the initial validation and characterization of a 3K chicken SNP array. World Poultry Science Journal. 64:219-225.

Polymorphisms of the bovine DAZL gene are associated with male fertility - (Abstract)

Liu, W., Wang, A., Zhang, H. 2008. Polymorphisms of the bovine DAZL gene are associated with male fertility [abstract]. Plant and Animal Genome Conference. p. 162.

Genetic bases for Marek's disease resistance - (Abstract)

Zhang, H., Heidari, M., Dunn, J.R., Yu, Y., Song, J. 2008. Genetic bases for Marek's disease resistance. Plant and Animal Genome Conference Proceedings. p. 96.

DNA methylation variations of TVB in ALV-resistant and -susceptible chickens - (Abstract)

Yu, Y., Zhang, H., Tian, F., Bacon, L.D., Song, J. 2008. Dna methylation variations of tvb in alv-resistant and -susceptible chickens [abstract]. Plant and Animal Genome Conference. p. 96.

Inhibition of avian tumor viruses by vector-based RNA interference - (Abstract)

Chen, M., Payne, W.S., Hunt, H.D., Zhang, H., Holmen, S.L., Dodgson, J.B. 2008. Inhibition of avian tumor viruses by vector-based RNA interference [abstract]. Plant and Animal Genome Conference. p. 257.

Genetic variation at the tumour virus B locus in commercial and laboratory chicken populations assessed by a medium-throughput or a high-throughput assay - (Peer Reviewed Journal)

Zhang, H.M., Bacon, L.D., Heidari, M., Muir, W.M., Groenen, M.A.M., Zhang, Y., Wong, G.K.S., Fulton, J.E., O'Sullivan, N.P., Albers, G.A.A., Vereijken, A.L.J., Rattink, A.P., Okimoto, R., McKay, J.C., McLeod, S., Cheng, H.H. 2007. Genetic variation at the tumour virus B locus in commercial and laboratory chicken populations assessed by a medium-throughput or a high-throughput assay. Avian Pathology. p. 283-291.

Characterization of LORF11, a unique gene common to the three Marek's disease virus serotypes - (Peer Reviewed Journal)

Lee, L.F., Silva, R.F., Cui, X., Zhang, H., Heidari, M., Reddy, S. 2007. Characterization of LORF11, a unique gene common to the three Marek's disease virus serotypes. Avian Diseases. 51:851-857.

Inhibition of avian leukosis virus replication by vector-based RNA interference - (Peer Reviewed Journal)

Chen, M., Granger, A.J., VanBrocklin, M.W., Payne, W.S., Hunt, H.D., Zhang, H.M., Dodgson, J.B., Holmen, S.L. 2007. Inhibition of avian leukosis virus replication by vector-based RNA interference. Virology. 365:464-472.

MDV-induced skin leukosis in scaleless chickens: tumor development in the absence of feather follicles - (Peer Reviewed Journal)

Heidari, M., Fitzgerald, S.D., Zhang, H.M., Silva, R.F., Lee, L.F., Dunn, J.R. 2007. MDV-induced skin leukosis in scaleless chickens: tumor development in the absence of feather follicles. Avian Diseases. 51(3):713-718.

Identification of a new splice variant of BDNF in chicken - (Abstract)

Yu, Y., Zhang, H.M., Bacon, L.D., Song, J. 2007. Identification of a new splice variant of BDNF in chicken [abstract]. Plant and Animal Genome VX Conference Abstracts. Paper #814. p. 305.

Putative evidence that genes outside the MHC have a significant influence on efficacy of Marek's disease vaccine - (Abstract)

Zhang, H.M., Dunn, J.R., Witter, R.L., Heidari, M., Bacon, L.D., Cui, Y., Song, J., Cheng, H.H. 2007. Putative evidence that genes outside the MHC have a significant influence on efficacy of Marek's disease vaccine [abstract]. Plant and Animal Genome VX Conference Abstracts. Paper #107. p. 128.

Exploring Rpe As a Source of Photoreceptors: Differentiation and Integration of Transdifferentiating Cells Grafted into Embryonic Chick Eyes - (Peer Reviewed Journal)

Liang, L., Yan, R., Ma, W., Zhang, H., Wang, S. 2006. Exploring RPE as a source of photoreceptors: differentiation and integration of transdifferentiating cells grafted into embryonic chick eyes. Investigative Ophthalmology and Visual Science. 47(11):5066-5076.

The Threshold of Genetic Susceptibility to Marek's Disease - (Abstract)

Zhang, H.M., Dunn, J.R., Heidari, M., Witter, R.L., Kulkarni, G., Bacon, L.D. 2006. The threshold of genetic susceptibility to Marek's disease [abstract]. 4th International Workshop on Molecular Pathogenesis of Marek's Disease Virus. p. 33.

Global Gene Expression Profiling During Cytolytic Infection of Marek's Disease Virus: Array Analysis of Host-Pathogen Interactions - (Abstract)

Heidari, M., Huebner, M., Zhang, H.M., Silva, R.F., Spatz, S.J., Kireev, D. 2006. Global gene expression profiling during cytolytic infection of Marek's disease virus: array analysis of host-pathogen interactions [abstract]. 4th International Workshop on Molecular Pathogenesis of Marek's Disease Virus. p. 8.

Effect of selection for resistance and susceptibility to viral diseases on concentrations of dopamine and immunological parameters in six-week-old chickens - (Peer Reviewed Journal)

Dennis, R., Zhang, H.M., Cheng, H.W. 2006. Effect of selection for resistance and susceptibility to viral diseases on concentrations of dopamine and immunological parameters in six-week-old chickens. Poultry Science. 85:2135-2140.

Skin Leukosis Induced by Mdv - (Abstract)

Heidari, M., Fitzgerald, S.D., Silva, R.F., Zhang, H.M. 2006. Skin leukosis induced by MDV [abstract]. American Association of Avian Pathologists and American Veterinary Medical Association Scientific Program. p. 176.

Exploring RPE as a source of photoreceptors: assessing cellular differentiation in vivo - (Abstract)

Liang, L., Zhang, H., Wang, S. 2006. Exploring RPE as a source of photoreceptors: assessing cellular differentiation in vivo [abstract]. Association for Investigative Opthalmology and Visual Science. E-abstract 5541.

Lymphoid Organ Size Varies among Inbred Lines 63, 72 and Their Thirteen Recombinant Congenic Strains of Chickens with the Same Mhc - (Peer Reviewed Journal)

Zhang, H.M., Hunt, H.D., Kulkarni, G.B., Palmquist, D.E., Bacon, L.D. 2006. Lymphoid organ size varies among inbred lines 63, 72 and their thirteen recombinant congenic strains of chickens with the same major histocompatibility complex. Poultry Science. 85:844-853.

Preliminary Results on the Validation and Application of 3,072 Chicken Snps by Genotyping 2,576 Commercial and Experimental Birds - (Abstract)

Cheng, H.H., Zhang, H.M., Muir, W.M., Groenen, M.A., Wong, G.K. 2006. Preliminary results on the validation and application of 3,072 chicken SNPs by genotyping 2,576 commercial and experimental birds [abstract]. Plant and Animal Genome XIV. p. 143.

Development and Validation of a Pcr-Rflp Assay to Evaluate Tvb Haplotypes Coding Receptors for Subgroup B and E Avian Leukosis Viruses in White Leghorns - (Peer Reviewed Journal)

Zhang, H.M., Bacon, L.D., Cheng, H.H., Hunt, H.D. 2005. Development and validation of a PCR-RFLP assay to evaluate TVB haplotypes coding receptors for subgroup B and subgroup E avian leukosis viruses in White Leghorns. Avian Pathology. 34(4):324-331.

Identification and Evaluation of Snps at the 3' End of the Tva Gene Segregating among Alsv Resistance and Susceptible Lines of Chickens - (Abstract)

Zhang, H.M., Hunt, H.D., Cheng, H.H., Dodgson, J.B., Romanov, M., Bacon, L.D. 2005. Identification and evaluation of SNPs at the 3' end of the tva gene segregating among ALSV resistance and susceptible lines of chickens [abstract]. Plant & Animal Genome XIII Conference. p. 197:123.

Retrospective Evidence That the Mhc (B Haplotype) of Chickens Influences Genetic Resistance to Attenuated Infectious Bronchitis Vaccine Strains in Chickens - (Peer Reviewed Journal)

Bacon, L.D., Hunter, D.B., Zhang, H.M., Brand, K., Etches, R. 2004. Retrospective evidence that the MHC (B haplotype) of chickens influences genetic resistance to attenuated infectious bronchitis vaccine strains in chickens. Avian Pathology. 33(6):605-609.

Behavioral and Physiological Features of Chickens Diversely Selected for Resistance to Avian Disease. 1. Selected Inbred Lines Differ for Behavioral and Physical Responses to Social Stress - (Peer Reviewed Journal)

Dennis, R., Zhang, H., Bacon, L.D., Esteves, I., Cheng, H. 2004. Behavioral and physiological features of chickens diversely selected for resistance to avian disease. 1. Selected inbred lines differ for behavioral and physical responses to social stress. Poultry Science. 83(9):1489.

Evaluation of Avian Leukosis Virus Subgroup a (Alva) and Subgroup B (Alvb) Receptor Genes in Recombinant Congenic Strains of Chickens - (Abstract)

Zhang, H., Bacon, L.D. 2004. Evaluation of avian leukosis virus subgroup A (ALVA) and subgroup B (ALVB) receptor genes in recombinant congenic strains of chickens [abstract]. International Conference on Animal Genetics. p. 115.

Oviductal Prolapse Led to More Than Eleven Percent of Hens Dead in a Highly Inbred Line of White Leghorn Chickens - (Abstract)

Zhang, H., Pandiri, A.R., Kulkarni, G. 2004. Oviductal prolapse led to more than eleven percent of hens dead in a highly inbred line of white leghorn chickens [abstract]. International Conference on Production Diseases in Farm Animals. p. 108.

Chicken Tubby-Like Protein 1 (Tulp1) Gene Maps to Chromosome 26 - (Peer Reviewed Journal)

Zhang, H.M., Cheng, H.H. 2004. Chicken tubby-like protein 1 (tulp1) gene maps to chromosome 26. Animal Genetics. 35:165-166.

Snp Identification and Genetic Mapping of Chicken Ephrin Type-B Receptor 2 Gene to Linkage Group E54 - (Peer Reviewed Journal)

Zhang, H.M., Cheng, H.H. 2004. SNP identification and genetic mapping of chicken ephrin type-B receptor 2 gene to linkage group E54. Animal Genetics. 35:162-163.

The Efficacy of Recombinant Fowlpox Vaccine Protection Against Marek's Disease: Its Dependence on Chicken Line and B Haplotype - (Peer Reviewed Journal)

Lee, L.F., Bacon, L.D., Yoshida, S., Yanagida, N., Zhang, H., Witter, R.L. 2004. The efficacy of recombinant fowlpox vaccine protection against marek's disease: its dependence on chicken line and b haplotype. Avian Diseases. 48:129-137.

A Pcr Based Snp Analysis of the Chicken Tvb Receptor Gene - (Abstract)

Zhang, H.M., Hunt, H.D., Cheng, H.H., Bacon, L.D. 2003. A PCR based SNP analysis of the chicken TVB receptor gene [abstract]. Poultry Science. 82(1):49.

Re-Establishment of a Transgenic Chicken Line 0-Alv6 at the Avian Disease and Oncology Laboratory - (Abstract)

Zhang, H., Bacon, L.D., Kulkarni, G. 2003. Re-establishment of a transgenic chicken line 0-ALV6 at the Avian Disease and Oncology Laboratory [abstract]. Poultry Science Association. 82(1):49.

Automation of Knowledge Discovery Processes in Biology Informatics - (Proceedings/Symposium) - (23-Jun-03)