Study of Hypothalamic Metabolism in Spontaneous Cluster Headache Attacks

This study has been terminated.

Sponsored by:	Assistance Publique Hopitaux De Marseille
Information provided by:	Assistance Publique Hopitaux De Marseille
ClinicalTrials.gov Identifier:	NCT00458770

Purpose

Cluster headache is characterized by unilateral excruciating head pain and autonomic dysfunction. Hypothalamic overactivity was observed in nitrate-induced cluster-headache and in only one case of spontaneous cluster headache 'Sprenger et al, 2004). This prompted the application of hypothalamic deep brain stimulation. The aim of this data is to precise the localisation of the hypothalamic activation.

Condition
Cluster Headache

MedlinePlus related topics: Headache

U.S. FDA Resources

Study Type:	Observational
Study Design:	Cohort, Prospective
Official Title:	Study of Hypothalamic Metabolism in Spontaneous Cluster Headache Attacks

Further study details as provided by Assistance Publique Hopitaux De Marseille:

Biospecimen Retention: None Retained

Biospecimen Description:

Estimated Enrollment:	10
Study Start Date:	March 2007
Estimated Study Completion Date:	March 2009

Eligibility

Ages Eligible for Study:	18 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Group of patients presenting an algie vascular of the face

Criteria

Inclusion Criteria:

cluster headache in crisis
no serious illnesses in progress as cancer, autoimmune disease, liver disease
patient without chronic psychiatric disease excluding moderate and reactional depression
no demential disease
no contraindication to PET scan (pregnancy and breast-feeding)
social security cover
written informed consent

Exclusion Criteria:

No effective contraception taken
Anable to realise a decubitus of 15 minutes long

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00458770

Locations

France
Pôle de Neurosciences Cliniques CHU Timone
MARSEILLE, France, 13005

Sponsors and Collaborators

Assistance Publique Hopitaux De Marseille

Investigators

Principal Investigator:

Anne DONNET, PH

Pôle de Neurosciences Cliniques CHU Timone, 204 rue St Pierre, Marseille 13385 cedex 5 France

More Information

Responsible Party:	Assistance Publique Hopitaux De Marseille ( Dr Anne DONNET )
Study ID Numbers:	2006/22
Study First Received:	April 10, 2007
Last Updated:	October 9, 2008
ClinicalTrials.gov Identifier:	NCT00458770
Health Authority:	France: Ministry of Health

Keywords provided by Assistance Publique Hopitaux De Marseille:

Comparison of a spontaneous acute cluster headache attack and rest (no pain) in ten patients with cluster headache defined with IHS criteria

Study placed in the following topic categories:

Cluster Headache
Signs and Symptoms
Headache
Neurologic Manifestations
Central Nervous System Diseases

Headache Disorders, Primary
Pain
Brain Diseases
Headache Disorders

Additional relevant MeSH terms:

Trigeminal Autonomic Cephalalgias
Nervous System Diseases

ClinicalTrials.gov processed this record on January 16, 2009