Prophylactic Effect of Memantine in Chronic Tension-Type Headache

This study has been completed.

Sponsored by:	Danish Headache Center
Information provided by:	Danish Headache Center
ClinicalTrials.gov Identifier:	NCT00315666

Purpose

The purpose of this study is to test whether memantine has a prophylactic effect on chronic tension-type headaches.

Condition	Intervention	Phase
Tension-Type Headache	Drug: memantine	Phase III

MedlinePlus related topics: Headache

Drug Information available for: Memantine Memantine hydrochloride

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Efficacy Study
Official Title:	Prophylactic Effect of Memantine in Chronic Tension-Type Headache

Further study details as provided by Danish Headache Center:

Primary Outcome Measures:

Headache duration
Headache intensity

Secondary Outcome Measures:

Headache frequency
The use of simple analgesics
Side effects

Estimated Enrollment:	40
Study Start Date:	May 2006
Study Completion Date:	June 2007
Primary Completion Date:	June 2007 (Final data collection date for primary outcome measure)

Eligibility

Ages Eligible for Study:	18 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Chronic tension-type headache
Normal urine pH

Exclusion Criteria:

More than 1 migraine attack/month
Other major illnesses
Overuse of medicine/alcohol
Women not using AC
Pregnant/breast-feeding women
Allergy to memantine

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00315666

Locations

Denmark
Danish Headaches Center
Glostrup, Denmark, DK-2600

Sponsors and Collaborators

Danish Headache Center

Investigators

Principal Investigator:

Lars Bendtsen, MD, PhD

Danish Headaches Center, Dept. of Neurology, KAS Glostrup, DK-2600 Glostrup

More Information

Study ID Numbers:	2006-000060-82, KA-20060021
Study First Received:	April 18, 2006
Last Updated:	August 28, 2008
ClinicalTrials.gov Identifier:	NCT00315666
Health Authority:	Denmark: Danish Medicines Agency

Keywords provided by Danish Headache Center:

Chronic tension-type headache

Study placed in the following topic categories:

Excitatory Amino Acids
Signs and Symptoms
Dopamine
Tension-Type Headache
Headache
Memantine

Central Nervous System Diseases
Neurologic Manifestations
Headache Disorders, Primary
Pain
Brain Diseases
Headache Disorders

Additional relevant MeSH terms:

Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Anti-Dyskinesia Agents
Therapeutic Uses
Physiological Effects of Drugs
Nervous System Diseases

Antiparkinson Agents
Excitatory Amino Acid Agents
Dopamine Agents
Central Nervous System Agents
Pharmacologic Actions
Excitatory Amino Acid Antagonists

ClinicalTrials.gov processed this record on January 16, 2009