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Sponsored by: |
National Institute of Neurological Disorders and Stroke (NINDS) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00023075 |
This study will use a magnetic resonance imaging technique called nuclear magnetic spectroscopy (H-MRS) to define the pathology and progression of primary lateral sclerosis, hereditary spastic paraplegia and amyotrophic lateral sclerosis and assess the usefulness of this technique in evaluating patients' response to therapy. H-MRS will be used to examine metabolic changes in the parts of the brain and spinal cord (motor cortex and corticospinal tract) involved in movement.
Normal volunteers and patients with primary lateral sclerosis, hereditary spastic paraplegia or amyotrophic lateral sclerosis between 21 and 65 years of age may be eligible for this study. Participants will have up to five H-MRS studies, including baseline and follow-up tests. For this procedure, the subject lies on a stretcher that is moved into a strong magnetic field. Earplugs are worn to muffle the loud knocking noise that occurs during switching of radio frequencies. The subject will be asked to lie still during each scan, for 1 to 8 minutes at a time. Total scanning time varies from 20 minutes to 2 hours, with most examinations lasting between 45 and 90 minutes. Communication with the medical staff is possible at all times during the scan.
Condition |
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Primary Lateral Sclerosis Hereditary Spastic Paraplegia Amyotrophic Lateral Sclerosis |
Study Type: | Observational |
Official Title: | Nuclear Magnetic Spectroscopy for the Evaluation of Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis |
Estimated Enrollment: | 55 |
Study Start Date: | August 2001 |
Estimated Study Completion Date: | August 2003 |
Standard MRI imaging of the brain shows no consistent abnormalities in many degenerative disorders with progressive upper motor neuron symptoms, including primary lateral sclerosis, hereditary spastic paraparesis, and amyotrophic lateral sclerosis. Nuclear magnetic resonance spectroscopy (H-MRS) is able to evaluate certain cerebral metabolites that reflect the functioning and integrity of neurons. The objective of this protocol is to study metabolic changes in the motor cortex and corticospinal tract using MRS in these disorders to characterize the pathology, the progression of the diseases, and assess the utility of MRS to follow the response to therapies.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
INCLUSION CRITERIA:
Adult patients with PLS, HSP, and ALS already evaluated by protocol #01-N-0148.
Adult normal volunteers
EXCLUSION CRITERIA:
Pregnancy, implanted devices such as pacemakers, medication pumps or defibrillators, metal in the cranium except the mouth, intracardiac lines, history of eye shrapnel injury or any other condition/device that may contraindicate or prevent the acquisition of an MRI.
Study ID Numbers: | 010241, 01-N-0241 |
Study First Received: | August 22, 2001 |
Last Updated: | March 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00023075 |
Health Authority: | United States: Federal Government |
Hereditary Spastic Paraplegia MRI Neuromuscular Disease N-Acetyl Aspartate Choline Creatine Spasms |
Spasticity Primary Lateral Sclerosis Spastic Paraparesis Healthy Volunteer HV Normal Control |
Spasm Spastic paraparesis Choline Spinal Cord Diseases Nervous System Malformations Roussy Levy hereditary areflexic dystasia Paraplegia Healthy Neurodegenerative Diseases Paraparesis, Spastic N-Methylaspartate Signs and Symptoms Heredodegenerative Disorders, Nervous System Musculoskeletal Diseases Neuromuscular Diseases |
Muscle Hypertonia Spastic Paraplegia, Hereditary Hereditary Motor and Sensory Neuropathies Congenital Abnormalities Motor Neuron Disease Hereditary spastic paraplegia Charcot-Marie-Tooth Disease Polyneuropathies Central Nervous System Diseases Sclerosis Degenerative motor system disease Motor neuron disease Paralysis Nerve Compression Syndromes Tomaculous neuropathy |
Neuromuscular Manifestations Pathologic Processes Nervous System Diseases |