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Sponsors and Collaborators: |
University Hospital, Geneva Ligue Pulmonaire Genevoise |
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Information provided by: | University Hospital, Geneva |
ClinicalTrials.gov Identifier: | NCT00557765 |
After exposure to an active case of tuberculosis (TB), close contacts may be infected. They are then considered as having latent tuberculosis infection (LTBI). Detecting LTBI is the main goal of contact tracing procedures after exposure to TB. Until recently, the only test available for detecting LTBI was the tuberculin skin test (TST). More recent tests are now available (Interferon-gamma release assays: IGRA), which are more specific and sensitive than the TST. This study compares the TST and an IGRA in the routine activity of contact tracing in our area.
Condition |
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Tuberculosis Latent Tuberculosis Infection |
Study Type: | Observational |
Study Design: | Case-Only, Prospective |
Official Title: | Production of Gamma-Interferon by Circulating Lymphocytes Exposed to Antigens Specific of Mycobacterium Tuberculosis: Contribution to the Identification of Latent Tuberculosis Infection in Contact Tracing |
Enrollment: | 295 |
Study Start Date: | October 2004 |
Study Completion Date: | January 2006 |
Setting: A TB clinic in Geneva, Switzerland, a low incidence area for TB with a high immigrant population.
Aim of study: to compare results of an IGRA test (T-SPOT.TB, Oxford Immunotec, UK) and the TST, and their correlation with exposure scores in subjects exposed to cases of contagious TB.
Methods: Prospective study of all contacts screened in our area, and accepting to be included. Simultaneous recording of age, gender, origin, history of recent travels or exposure, BCG vaccination status, infectiousness of index case, 5 different exposure scores, TST, and result of the T-SPOT.TB blood test. Univariate and multivariate analysis.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
All subjects screened after exposure to a case of active and contagious tuberculosis in the Geneva area
Inclusion Criteria:
Exclusion Criteria:
Switzerland | |
Centre antituberculeux; Geneva University Hospital | |
Geneva, Switzerland, 1211 |
Principal Investigator: | Jean-Paul Janssens, M.D. | Centre antituberculeux |
Study ID Numbers: | 04-184 |
Study First Received: | November 13, 2007 |
Last Updated: | November 13, 2007 |
ClinicalTrials.gov Identifier: | NCT00557765 |
Health Authority: | Switzerland: Ethikkommission |
Tuberculosis Latent tuberculosis infection Interferon gamma release assay Contact tracing |
Bacterial Infections Gram-Positive Bacterial Infections Interferon Type II Interferons |
Mycobacterium Infections Tuberculosis Interferon-gamma, Recombinant |
Communicable Diseases Infection Actinomycetales Infections |