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3,3-Dimethylbenzidine (CASRN 119-93-7)
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0538
3,3-Dimethylbenzidine; CASRN 119-93-7
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR 3,3-Dimethylbenzidine
File First On-Line 07/01/1991
Category (section) |
Status |
Last Revised |
|---|---|---|
| Oral RfD Assessment (I.A.) | no data | |
| Inhalation RfC Assessment (I.B.) | message | 07/01/1991 |
| Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — 3,3-Dimethylbenzidine
CASRN — 119-93-7
Not available at this time.
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — 3,3-Dimethylbenzidine
CASRN — 119-93-7
The health effects data for 3,3'-dimethylbenzidine were reviewed by the U.S. EPA RfD/RfC Work Group and determined to be inadequate for derivation of an inhalation RfC. The verification status of this chemical is currently not verifiable. For additional information on the health effects of this chemical, interested parties are referred to the EPA documentation listed below.
U.S. EPA. 1987. Health and Environmental Effects Profile for 3,3'- Dimethylbenzidine. Prepared by the Office of Health and Environmental Assessment, Environmental Criterial and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
Agency Work Group Review — 03/28/1991
EPA Contacts:
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfC for 3,3-Dimethylbenzidine conducted in August 2003 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or 202-566-1676.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — 3,3-Dimethylbenzidine
CASRN — 119-93-7
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — 3,3-Dimethylbenzidine
CASRN — 119-93-7
Last Revised — 07/01/1991
_VI.A. Oral RfD References
None
_VI.B. Inhalation RfC References
U.S. EPA. 1987. Health and Environmental Effects Profile for 3,3'- Dimethylbenzidine. Prepared by the Office of Health and Environmental Assessment, Environmental Criterial and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — 3,3-Dimethylbenzidine
CASRN — 119-93-7
|
Date |
Section |
Description |
|---|---|---|
| 07/01/1991 | I.B. | Inhalation RfC message on-line |
| 07/01/1991 | VI. | Bibliography on-line |
| 01/01/1992 | IV. | Regulatory Action section on-line |
| 04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
| 10/28/2003 | I.B. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — 3,3-Dimethylbenzidine
CASRN — 119-93-7
Last Revised — 07/01/1991
- 119-93-7
- (1,1'-Biphenyl)-4,4'-diamine, 3,3'-dimethyl-
- Benzidine, 3,3'-dimethyl-
- Bianisidine
- C.I. AZOIC DIAZO COMPONENT 113
- C.I. 37230
- Diaminoditolyl
- FAST DARK BLUE BASE R
- HSDB 1640
- o-TOLIDIN
- o-Tolidine
- o,o'-TOLIDINE
- Orthotolidine
- RCRA WASTE NUMBER U095
- 2-TOLIDIN [German]
- 2-TOLIDINA [Italian]
- 2-tolidine
- 3,3'-Dimethyl-(1,1'-biphenyl)-4,4'-diamine
- 3,3'-DIMETHYL-4,4'-BIPHENYLDIAMINE
- 3,3'-DIMETHYL-4,4'-DIAMINOBIPHENYL
- 3,3'-DIMETHYL-4,4'-DIPHENYLDIAMINE
- 3,3'-DIMETHYLBENZIDIN
- 3,3'-dimethylbenzidine
- 3,3'-DIMETHYLBIPHENYL-4,4'-DIAMINE
- 3,3'-DIMETHYLDIPHENYL-4,4'-DIAMINE
- 3,3'-TOLIDINE
- 4,4'-BI-o-TOLUIDINE
- 4,4'-DI-o-TOLUIDINE
- 4,4'-DIAMINO-3,3'-DIMETHYLBIPHENYL
- 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYL