Changes to This Summary (04/24/2009)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Major Genes
Added text to state that a classification and reporting system may be useful in the management of patients with a variant of uncertain significance (cited Plon et al. as reference 27).
Added Spearman et al., and Goldgar et al., and Couch et al. as references 32, and 33, and 38, respectively.
Added text to state that performance of risk assessment models can vary in specific ethnic groups (cited Kurian et al. as reference 78).
Low Penetrance Predisposition to Breast and Ovarian Cancer
Added Wasielewski et al. as reference 24.
Interventions
The Pelvic Ultrasound subsection was renamed Transvaginal Ultrasound and the subsection was extensively revised.
Added text to state that serum CA 125 screening for ovarian cancer in high-risk women has been evaluated in combination with TVUS in a number of retrospective studies.
Psychosocial Issues in Inherited Breast Cancer Syndromes
Added text about a study that stated men reported greater difficulty disclosing mutation-positive results to family members in comparison to women (cited Finlay et al. as reference 108).
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