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The Oswald T. Avery Collection

Title:
Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: III. An Improved Method for the Isolation of the Transforming Substance and Its Application to Pneumococcus Types II, III, and VI pdf (789,682 Bytes) ocr (23,887 Bytes)
Description:
In this second of two direct follow-ups to the 1944 paper on the Transforming Principle, Avery and McCarty provided further details of experimentation which showed that citrate (a salt or ester of citric acid) acted as a powerful inhibitor of enzymatic action on DNA, thus resulting in high yields of transforming DNA during experiments. Later, McCarty wrote that when one considered the combined data of the three papers, "there was not much room left for the skeptics to advance sensible alternatives to the view that DNA was the active substance in transformation."
Item is a photocopy.
Number of Image Pages:
8 (789,682 Bytes)
Date:
1946-01 (January 1946)
Creator:
McCarty, Maclyn
Avery, Oswald T.
Source:
Periodical: McCarty, Maclyn, and Oswald T. Avery. "Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: III. An Improved Method for the Isolation of the Transforming Substance and Its Application to Pneumococcus Types II, III, and VI." Journal of Experimental Medicine 83, 2 (January 1946): 97-104. Article. 8 Images.
Publisher:
Rockefeller University Press
Rights:
Reproduced from the Journal of Experimental Medicine, 1946, 83, 97-104, by copyright permission of the Rockefeller University Press.
Exhibit Categories:
DNA as the "Stuff of Genes": The Discovery of the Transforming Principle, 1940-1944
After the Discovery: The Transforming Principle's Reception by the Scientific Community
Relation:
Metadata Record Letter from Oswald T. Avery to Roy Avery [13, 26 May 1943]
Metadata Record Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type III (February 1944)
Metadata Record Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: II. Effect of Desoxyribonuclease on the Biological Activity of the Transforming Substance (January 1946)
Unique Identifier:
CCGMDB
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Folder: [Selected articles collected by NLM]
Metadata Last Modified Date:
2006-11-15
U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894
National Institutes of Health, Department of Health & Human Services
USA.gov, Copyright, Privacy, Accessibility
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