Topic:	Digestive Diseases (DD)
Title:	Appendectomy Is Followed by Increased Risk of Crohn's Disease.
Author:	Andersson, R.E., et al.
Source:	Gastroenterology. 124(1): 40-46. 2003.
Availability:	Available from W.B. Saunders Company. 6277 Sea Harbor Drive, Orlando, FL 32887-4800. (800) 654-2452. Website: www.gastrojournal.org.
Abstract:	Appendectomy is associated with a low risk of subsequent ulcerative colitis (UC, a type of inflammatory bowel disease). This article reports on a study of the risk of Crohn's disease (a second type of inflammatory bowel disease) after appendectomy. The authors followed-up 212,218 patients with appendectomy before age 50 years and a cohort of matched controls, identified from the Swedish Inpatient Register and the nationwide Census, for any subsequent diagnosis of Crohn's disease. An increased risk of Crohn's disease was found for more than 20 years after appendectomy, with incidence rate ratio 2.11 after perforated appendicitis, 1.85 after nonspecific abdominal pain, 2.15 after mesenteric lymphadenitis, 2.52 after other diagnoses. After nonperforated appendicitis, there was an increased risk among women but not among men. Patients operated on before age 10 years had a low risk. Crohn's disease patients with a history of perforated appendicitis had a worse prognosis. 2 figures. 5 tables. 29 references.
Format:	Journal Article
Language:	English.
Major Keywords:	Digestive System Diseases. Crohns Disease. Etiology. Risk Factors. Appendectomy. Postoperative Complications.
Minor Keywords:	Inflammatory Bowel Disease. Sex Factors. Age Factors. Incidence. Diagnosis. Appendicitis. Emergencies. Abdominal Pain.
Publication Number:	DDJA09414
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