Redox Reactions in Antigen Processing |
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| Air date: | Wednesday, March 20, 2002, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. Topics include the function of a gamma interferon inducible lysosomal enzyme (GILT) which reduces disulfide bonds in proteins. Its localization in class II-positive intracellular compartments in APCs suggested a role in antigen processing, and the enzymatic activity suggested that responses to antigens containing disulfide bonds might be affected. This was confirmed by analysis of GILT knock-out mice, which have clear deficiencies in generating CD4 T cell responses to such antigens. Peter Cresswell, Ph.D., HHMI, Professor, Deptartment of Immunobiology, Yale University School of Medicine For more information, visit http://www.med.yale.edu/immuno/fac_cresswell.html |
| Author: | Peter Cresswell, Ph.D., Yale University School of Medicine |
| Runtime: | 60 minutes |
| Rights: | This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely. |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 10207 |
| CIT Live ID: | 946 |
| Permanent link: | http://videocast.nih.gov/launch.asp?10207 |