Regulating T Cell Antigen Receptor Signaling |
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| Launch in standalone player | |
| Air date: | Wednesday, March 19, 2003, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | The NIH Director's Wednesday Afternoon Lecture Series
Signal transduction by the T cell antigen receptor (TCR) is initiated through the sequential interaction of the receptor with Src and Syk kinases. Tyrosine phosphatases play a key role in regulating the activation of kinases and their downstream phosphorylation events. CD45, an abundant receptor-like protein tyrosine phosphatase (RPTP) on all nucleated hematopoietic cells, is required for antigen receptor-mediated signaling. One function of CD45 is to positively regulate Src kinases. However, although CD45 is a receptor-like protein, the mechanism by which its function is regulated was not known. We obtained evidence that dimerization of the CD45 cytoplasmic domain negatively regulates its function. For more information, visit Arthur Weiss |
| Author: | Arthur Weiss, M.D., Ph.D., UCSF |
| Runtime: | 60 minutes |
| Rights: | This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely. |
| Download: | Download
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| CIT File ID: | 10206 |
| CIT Live ID: | 1887 |
| Permanent link: | http://videocast.nih.gov/launch.asp?10206 |