Spraker, T.R., Vercauteren, K.C., Gidlewski, T., Schneider, D.A., Munger, R., Balanchandran, A., Orourke, K.I. 2009. Antemortem detection of PrP-CWD in preclinical, ranch-raised Rocky Mountain elk (Cervus elaphus nelsoni) by biopsy of the rectal mucosa. Journal of Veterinary Diagnostic Investigation. 21(1):15-24.
Schneider, D.A., Yan, H., Fry, L.M., Alverson, J., White, S.N., Orourke, K.I. 2008. Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie. Acta Neuropathologica. 115(6):651-661.
Evoniuk, J., Johnson, M., Borowicz, P., Caton, J.S., Vonnahme, K., Reynolds, J., Taylor, J.B., Stoltenow, C., Orourke, K.I., Redmer, D. 2008. Effects of Nutrition and Genotype on Prion Protein (PrPC) Gene Expression in the Fetal and Maternal Sheep Placenta. Placenta. 29(5):422-428.
Greenlee, J.J., O'Rourke, K.I., Hamir, A.N., Gidlewski, T., Zhuang, D., Spraker, T. 2007. Prolonged CWD Incubation Time and Unique PrP**d Profile in Prnp 132LL Elk. In: Proceedings of the U.S. Animal Health Association 111th Annual Meeting, Captive Wildlife and Alternative Livestock Committee, October 20, 2007, Reno, Nevada. p. 264-265.
Zheng, M., Qing, L., Huang, S., Chen, F., Wang, M., Wang, L., Miller, M., Hamir, A.N., Richt, J.A., O'Rourke, K., Belay, E.D., Schonberger, L.B., Gambetti, P., Kong, Q. 2007. Assessment of direct and indirect transmission of CWD from three cervid species to humans [abstract]. Prion 2007. Paper No. FC5.8.
O'Rourke, K.I., Spraker, T.R., Zhuang, D., Greenlee, J.J., Gidlewski, T.E., Hamir, A.N. 2007. Elk with a long incubation prion disease phenotype have a unique PrP-d profile. NeuroReport. 18(18):1935-1938.
Evoniuk, J.M., Berg, P., Johnson, M.L., Larson, D.M., Maddock, T., Stoltenow, C.L., Schauer, C.S., Orourke, K.I., Redmer, D.A. 2007. Association between genotypes at codon 171 and 136 of the prion protein gene and production traits in market lambs. American Journal of Veterinary Research. 68(10):1073-1078.
Spraker, T, Greenlee, J., Gidlewski T., O¿Rourke, K. 2007. Abnormal Prion Protein in the Retina of Rocky Mountain Elk (Cervus Elaphus Nelsoni) [abstract]. Prion 2007. Paper No. P03.70. p. 64.
Spraker, T., Gidleweski, T., Greenlee, J., Keane, D., Hamir, A., Orourke, K. 2007. Detection of PrP**CWD in retinal tissues in white-tailed deer (Odocoileus virginianus) and Rocky Mountain elk (Cervus elaphus nelsoni) with CWD [abstract]. American Association of Veterinary Laboratory Diagnosticians 50th Annual Meeting. p. 47.
Kehrli, Jr., M.E., O'Rourke, K.I., Hamir, A.N., Richt, J.A., Nicholson, E.M., Silva, C.J., Edelman, D., Gay, C.G. 2007. Pathobiology and diagnosis of animal transmissible spongiform encephalopathies: current knowledge, research gaps, and opportunities [government white paper]. Beltsville, MD: Interagency Working Group on Prion Science, Subcommittee on Pathobiology and Diagnostics. USDA, Agriculture Research Service. 33 p.
Johnson, M.L., Evoniuk, J.M., Stoltenow, C.L., Orourke, K.I., Redmer, D.A. 2007. Development of an assay to determine single nucleotide polymorphisms in the prion gene for the genetic diagnosis of relative susceptibility to classical scrapie in sheep. Journal of Veterinary Diagnostic Investigation. 19:73-77.
Alverson, J., O'Rourke, K.I., Baszler, T.V. 2006. PrPSc accumulation in fetal cotyledons of scrapie-resistant lambs is influenced by fetus location in the uterus. Journal of General Virology. 87:1035-1041.
Baszler, T.V., Kiupel, M., Williams, E.S., Thomsen, B.V., Gidlewski, T., Montgomery, D.L., O'Rourke, K.I., Hall, S.M. 2006. Comparison of two automated immunohistochemical procedures for the diagnosis of scrapie in domestic sheep and chronic wasting disease in north American white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus). Journal of Veterinary Diagnostic Investigation. 18(2):147-155.
Kong, Q., Huang, S., Zou, W., Vanegas, D., Wang, M., Wu, D., Yuan, J., Zheng, M., Bai, H., Deng, H., Chen, K., Allen, J., O'Rourke, K.I., Belay, E.D., Schonberger, L.B., Petersen, R.B., Sy, M., Chen, S.G., Gambetti, P. 2005. Chronic Wasting Disease of Elk: Transmissibility to Humans Examined by Transgenic Mouse Models. The Journal of Neuroscience. 25(35):7944-7949.
Evoniuk, J.M., Stoltenow, C.L., O'Rourke, K.I., Moore, B.L., Redmer, D.A. 2005. Assessment of the genetic risk and impact of lateral transmission in a valine-associated scrapie outbreak in sheep. American Journal of Veterinary Research. 66(8):1-6.
Johnson, M.L., Evoniuk, J.M., Stoltenow, C.L., Orourke, K.I., Redmer, D.A. 2005. Development of an assay to determine single nucleotide polymorphisms (snp) in the prion gene for the diagnosis of genetic susceptibility to scrapie in sheep. American Society of Animal Science. 56:151.
Huang, H., Rendulich, J., Stevenson, D., O'Rourke, K.I., Balachandran, A. 2005. Evaluation of Western blotting methods using samples with or without sodium phosphotungstic acid precipitation for diagnosis of scrapie and chronic wasting disease. Canadian Journal of Veterinary Research. 69(3):193-199.
Huang, H., Rendulich, J., Stevenson, D., Orourke, K.I., Balachandran, A. 2005. Evaluation of Western blotting methods using samples with or without sodium phosphotungstic acid precipitation for diagnosis of scrapie and chronic wasting disease. Canadian Journal of Veterinary Research. 69(3):193-199.
Alexander, B.M., Stobart, R.H., Russell, W.C., Orourke, K.I., Lewis, G.S., Logan, J.R., Duncan, J.R., Moss, G.E. 2005. The incidence of genotypes at codon 171 of the prion protein gene (prnp) in five breeds of sheep and production traits of ewes associated with those genotypes. Journal of Animal Science. 83(2):455-459.
Hamir, A.N., Kunkle, R.A., Richt, J.A., Cutlip, R.C., Miller, J.M., Orourke, K.I., Williams, E.S., Miller, M.W., Stack, M.J., Chaplin, M.J. 2004. Experimental transmission of chronic wasting disease agent to cattle by intracerebral route: final outcome of the study [abstract]. Animal Prion Diseases and the Americas. p. 78.
Hamir, A.N., Kunkle, R.A., Richt, J.A., Cutlip, R.C., Miller, J.M., O'Rourke, K.I., Williams, E.S., Miller, M.W., Stack, M.J., Chaplin, M.J. 2004. Experimental transmission of chronic wasting disease agent to cattle by intracerebral route: final outcome of the study [abstract]. Annual Conference of the American College of Veterinary Pathologists. 41:588.
Caplazi, P., O'Rourke, K.I., Wolf, C., Shaw, D., Baszler, T. 2004. Biology of PrP-Sc accumulation in two naturally scrapie-infected sheep flocks. Journal of Veterinary Diagnostic Investigation. 16(6):489-496.
O'Rourke, K.I., Spraker, T.R., Hamburg, L.K., Besser, T.E., Brayton, K.A., Knowles, D.P. 2004. Polymorphisms in the prion precursor functional gene but not the pseudogene are associated with susceptibilty to chronic wasting disease in white-tailed deer. Journal of General Virology. 85:1339-1346.
Caplazi, P., Orourke, K.I., Baszler, T.V. 2004. Resistance to scrapie in prp arr/arq heterozygous sheep is not caused by preferential allelic usage. Journal of Clinical Pathology. 57:647-650.
Spraker, T.R., Balachandran, A., Zhuang, D., O'Rourke, K.I. 2004. Variable patterns of distribution of PrP(CWD) in the obex and cranial lymphoid tissues of Rocky Mountain elk (Cervus elaphus nelsoni) with subclinical chronic wasting disease. Veterinary Record. 155(10):295-302.
Hamir, A.N., Miller, J.M., Cutlip, R.C., Richt, J.A., Kunkle, R.A., O'Rourke, K.I., Jenny, A.L., Stack, M.J., Chaplin, M.J. 2003. Transmission of sheep scrapie to elk (Cervus elaphus nelsoni) by intracerebral inoculation. 46th Annual Meeting of the American Association of Veterinary Laboratory Diagnosticians. p. 210.
Hamir, A.N., Cutlip, R.C., Miller, J.M., Richt, J.A., Kunkle, R.A., Williams, E., Stack, M.J., Chaplin, M.J., Miller, M., O'Rourke, K.I. 2003. Experimental cross-species transmission of chronic wasting disease (CWD-mule deer) to domestic livestock at the National Animal Disease Center: An update [Abstract]. 46th Annual Meeting of the American Association of Veterinary Laboratory Diagnosticians. p. 209.
Bender, S., Alverson, J., Herrmann, L.M., O'Rourke, K.I. 2004. Histamine as an aid to biopsy of third eyelid lymphoid tissue in sheep. Veterinary Record. 154: 662-663.
Hamir, A.N., Cutlip, R.C., Miller, J.M., Richt, J.A., Kunkle, R.A., Williams, E., Stack, M., Miller, M.W., O'Rourke, K.I., Chaplin, M.J. 2003. Experimental cross-species transmission of chronic wasting disease to domestic livestock at the National Animal Disease Center: An update [Abstract]. International Conference on Emerging Zoonoses. p. 91.
Alverson, J., Bender, S., Herrmann, L.M., Orourke, K.I. 2003. Third eyelid lymphoid tissue biopsy in sheep is aided by histamine [abstract]. Proceedings of the American Association of Veterinary Laboratory Diagnosticians 46th Annual Conference. 41: 212.
Hamir, A.N., Cutlip, R.C., Miller, J.M., Richt, J.A., Kunkle, R.A., Williams, E., Stack, M., Chaplin, M., Miller, M., O'Rourke, K.I. 2003. Experimental cross-species transmission of chronic wasting disease (CWD-mule deer) to domestic livestock at the National Animal Disease Center: An update [Abstract]. 52nd Annual Wildlife Disease Association Conference. p. 134.
HAMIR, A.N., CUTLIP, R.C., MILLER, J.M., RICHT, J., KUNKLE, R.A., WILLIAMS, E., STACK, M., CHAPLIN, M., MILLER, M., OROURKE, K.I. EXPERIMENTAL CROSS-SPECIES TRANSMISSION OF CHRONIC WASTING DISEASE (CWD-MULE DEER) TO DOMESTIC LIVESTOCK AT THE NATIONAL ANIMAL DISEASE CENTER: AN UPDATE. DISEASES AT THE INTERFACE BETWEEN DOMESTIC LIVESTOCK AND WILDLIFE SPECIES. 2003. ABSTRACT NO. 8.
Paramithiotis, E., Pinard, M., Lawton, T., Laboissiere, S., Leathers, S., Zou, W., Estey, L., Lamontagne, J., Lehto, M.T., Kondejewski, L.H., Francoeur, G.P., Papadopoulos, M., Haghighat, A., Spatz, S.J., Head, M., Will, R., Ironside, J., Orourke, K.I., Tonelli, Q., Ledebur, H.C., Chakrabartty, A., Cashman, N.R. 2003. A prion protein epitope selective for the pathologically misfolded conformation. Nature Medicine. 9(7):893-899.
O'Rourke, K.I., Zhuang, D., Lyda, A.K., Gomez, G., Williams, E.S., Tuo, W., Miller, M.W. Abundant PrP-CWD in tonsil from mule deer with preclinical chronic wasting disease. Journal of Diagnostic Investigation. 2003. v. 15. 320-323.
Wild, M.A., Spraker, T.R., Sigurdson, C.J., Orourke, K.I., Miller, M.A. 2002. Preclinical diagnosis of chronic wasting disease in captive mule deer (odocoileus heminonus) and white tailed deer (odocoileus virginianus) using tonsillar biopsy. Journal of General Virology. 83: 2629-2634.
Spraker, T.R., Zink, R.R., Cummings, B.A., Sigurdson, C.J., Miller, M.W., O'Rourke, K.I. Distribution of protease-resistant prion protein and spongiform encephalopathy in free-ranging mule deer (Odocoileus hemionus) with chronic wasting disease. Veterinary Pathology. 2002. v. 39. p. 546-556.
Valdez, R.A., Rock, M.J., Anderson, A.K., O'Rourke, K.I. 2003. Immunohistochemical detection and distribution of prion protein in a goat with natural scrapie. Journal of Veterinary Diagnostic Investigation. 15(2):157-162.
Van Everbroeck, B., O'Rourke, K.I., Cras, P. 1999. Immunoreactivity of the monoclonal antibody F89/160.1.5 for the human prion protein. Eur. J. Histochem. 43(4):335-338.