NOTICE OF LIMITED COMPETITION REQUEST FOR COMPETING APPLICATIONS: NHLBI THALASSEMIA CLINICAL RESEARCH NETWORK RELEASE DATE: October 3, 2003 NOTICE: NOT-HL-03-017 National Heart, Lung, and Blood Institute (NHLBI) (http://www.nhlbi.nih.gov) APPLICATION RECEIPT DATE: October 19, 2004 The NHLBI is requesting competing renewal applications from the six grants currently funded as part of the Thalassemia Clinical Research Network. These awards resulted from RFA HL-99-016, Thalassemia Clinical Research Network (http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-99-016.html). This network provides a unique collaborative structure for clinical studies. The extensive time and processes involved in establishing the collaboration essential for efficient development and implementation of protocols as a network warrants this limited re-competition for one renewal cycle. The experience gained by the current group of investigators in working together, designing protocols suitable for a clinical research network setting, and maintaining high quality follow-up data is considerable. Keeping the group in tact for one more grant award cycle will take maximum advantage of this experience. Should the grants be successfully reviewed, the current network will continue for five more years, depending on the availability of funds. After that point, the NHLBI will determine the feasibility of maintaining a clinical research network in thalassemia and, if appropriate, the NHLBI will issue an entirely new request for applications as an unlimited competition. MECHANISM OF SUPPORT The network uses the cooperative agreement (U01) administrative and funding mechanism of support. Under the cooperative agreement, the NIH assists, supports, and/or stimulates, and is substantially involved with recipients in conducting a study by facilitating performance of the effort in a "partner" role. Details of the responsibilities, relationships, and governance of a study funded under this cooperative agreement will be the same as in the current terms and conditions of the award. Organization, Operation, and Oversight remain unchanged from the original RFA. SUBMITTING AN APPLICATION Applications must be prepared using the PHS 398 research grant application instructions and forms (rev. 5/2001). Applications must have a Dun and Bradstreet (D&B) Data Universal Numbering System (DUNS) number as the Universal Identifier when applying for Federal grants or cooperative agreements. The DUNS number can be obtained by calling (866) 705-5711 or through the web site at http://www.dunandbradstreet.com/. The DUNS number should be entered on line 11 of the face page of the PHS 398 form. The PHS 398 is available at http://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive format. For further assistance contact GrantsInfo, Telephone (301) 435-0714, Email: GrantsInfo@nih.gov. Only competing renewal applications which were funded as part of RFA-HL-99-016, Thalassemia Clinical Research Network, will be considered. Item 2 on the Face Page should be checked "Yes"; after "Number:" enter "NOT-HL-03-017" and after "Title:" enter "Competing Applications for Thalassemia Network". For the Checklist at the end of the application, mark the box "Competing Continuation", and fill in the grant application number. Submit a signed, typewritten original of the application, including the Checklist, and three signed, photocopies, in one package to: Center For Scientific Review National Institutes Of Health 6701 Rockledge Drive, Room 1040, MSC 7710 Bethesda, MD 20892-7710 Bethesda, MD 20817 (for express/courier service) At the time of submission, two additional copies of the application plus all five collated sets of appendix material must be sent to: Anne P. Clark, Ph.D. Chief, Review Branch National Heart, Lung, and Blood Institute National Institutes of Health 6701 Rockledge Drive, Room 7214 Bethesda, MD 20892-7924 Bethesda, MD 20817 (for express/ courier service) Telephone: 301-435-0270 FAX: 301-480-0730 email: clarka@nhlbi.nih.gov Applications must be received on or before the application receipt date listed in the heading of this Notice.
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