Chief, Gene Transfer Section 
NATIONAL INSTITUTES OF HEALTH/NIDCR
BUILDING 10 ROOM 1N113
10 CENTER DR MSC 1190
BETHESDA MD 20892-1190
Phone: (301) 496-1363
Fax: (301) 402-1228
E-mail: Dr. Bruce J. Baum
Research Interests
Clinical applications of gene transfer technology; Regulation of salivary gland secretion.
Education
B.A., University of Virginia, 1967
D.M.D., Tufts University, 1971
Ph.D., Boston University, 1974
Recent publications
Shan, Z., Li, J., Zheng, C., Liu, X., Zhang, C., Goldsmith, C.M., Wellner, R.B., Baum, B.J. and Wang, S. Increased fluid secretion after adenoviral-mediated transfer of the human aquaporin-1 cDNA to irradiated miniature pig parotid glands. Mol. Ther. 11: 444-451, 2005.
Cotrim, A.P., Sowers, A.L., Lodde, B.M., Vitolo, J.M., Kingman, A., Russo, A., Mitchell, J.B. and Baum, B.J. Kinetics of Tempol for prevention of xerostomia following head and neck irradiation in a mouse model. Clin. Cancer Res. 11: 7564-7568, 2005.
Wang, J., Voutetakis, A., Papa, M., Rivera, V.M., Clackson, T., Lodde, B.M., Mineshiba, F. and Baum, B.J. Rapamycin control of transgene expression from a single AAV vector in mouse salivary glands. Gene Ther. 13: 187-190, 2006.
Wang, J., Voutetakis, A., Mineshiba, F., Illei, G.G., Dang, H., Yeh, C.-K. and Baum, B.J. The effect of serotype 5 adenoviral and serotype 2 adeno-associated viral vector- mediated gene transfer to salivary glands on the composition of saliva. Hum. Gene Ther. 17: 455-463, 2006.
Zheng, C., Goldsmith, C.M., Mineshiba, F., Chiorini, J.A., Kerr, A., Wenk, M.L.,Vallant, M., Irwin, R.D. and Baum,B.J. Toxicity and biodistribution of a first-generation recombinant adenoviral vector encoding aquaporin-1 after retroductal delivery to a single rat submandibular gland. Hum. Gene Ther. 17: 1122-1133, 2006.
Baum, B.J. Inadequate training in the biological sciences and medicine for dental students: An impending crisis for dentistry. J. Amer. Dent. Assoc. 138: 16-25, 2007.
Voutetakis, A., Zheng, C., Mineshiba, F., Cotrim, A.P., Goldsmith, C.M., Schmidt, M., Afione, S., Roescher, N., Metzger, M., Eckhaus, M.A., Chiorini, J.A., Dunbar, C.E., Donahue, R.E., and Baum, B.J. AAV2-mediated gene transfer to the parotid glands of non-human primates. Hum. Gene Ther. 18:142-150, 2007.
Yan, X., Voutetakis, A., Zheng, C., Hai, B., Zhang, C., Baum, B.J. and Wang, S. Sorting of transgenic secretory proteins in miniature pig parotid glands following adenoviral-mediated gene transfer. J. Gene Med. 9:779-787, 2007.
Cotrim, A.P., Sowers, A., Mitchell, J.B., and Baum, B.J. Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands. Mol Ther. 15:2101-2106, 2007.
Voutetakis, A., Zheng, C., Wang, J., Goldsmith, C.M., Afione, S., Chiorini, J.A., Wenk, M.L., Vallant, M., Irwin, R.D. and Baum, B.J. Gender differences in serotype 2 adeno-associated virus biodistribution after administration to rodent salivary glands. Hum. Gene Ther. 18:1109-1118, 2007.
Current Clinical Protocol
“Open-label, dose-escalation study evaluating the safety of a single administration of an adenoviral vector encoding human aquaporin-1 to one parotid salivary gland in individuals with irradiation-induced parotid salivary hypofunction”, NIH study # 06-D-0206, FDA IND #13102
See the clinical trial website