Table 1. Comparison of results between the NCI/NTP 2 yearbioassay in B6C3F1 mice and in 24 week studiesa in heterozygous p53 (+/-)deficient (C57BL/6) mice.

http://ntp.niehs.nih.gov/go/1929

				B6C3F₁	p53^def
Chemical	TR No.	SAL^b	Route	Target Organ	Results
p-Anisidine	115	+	Feed	None	-
Benzene	289	-^c; +^d	Gavage	Multiple Sites	+
p-Cresidine	142	+	Feed	Bladder, Liver	+
4-Vinyl-1-cyclohexene diepoxide	362	+	Skin Paint	Skin, Ovary	+
N-Methyl-o-acrylamide	352	-	Gavage	Kidney, Liver	-
Reserpine	193	-	Feed	Mammary	-

^a Replication of the NCI/NTP 2 year bioassay using the same route of administration and dose range.
^b In vitro Salmonella mutagenesis assay
^c In vitro Salmonella mutagenesis assay negative
^d In vivo micronucleus assay positive

Web page last updated on June 09, 2005

National Toxicology Program

Table 1. Comparison of results between the NCI/NTP 2 yearbioassay in B6C3F1 mice and in 24 week studiesa in heterozygous p53 (+/-)deficient (C57BL/6) mice.