When should the Office of Research Oversight (ORO) be notified of a research misconduct allegation?
The RIO should first notify ORO Central Office of a research misconduct allegation when an Inquiry is opened.  Paragraph 14.c.(2)(d).  This written notice should include the name of the Respondent(s), the nature of and basis for the allegation, and the research funding involved.  Paragraph 14.c.(3).

ORO Central Office must be further notified:

• if an Inquiry determines that the case should be closed without further Investigation (par. 14.g.(2));
• when an Investigation is initiated (par. 15.c.);
• at the end of an Investigation (par. 15.h.(3));
• when interim actions are taken in response to certain events, e.g., harm to research subjects, serious violations of animal welfare requirements, research safety compromises, etc. (par. 12.e.(1)).