RFP ANNOUNCEMENT: RESPIRATORY PATHOGENS REFERENCE LABORATORY - NIH-NIAID-DMID-03-37 Release Date: NOTICE: NOT-AI-02-037 National Institute of Allergy and Infectious Diseases (NIAID) (http://www.niaid.nih.gov) Receipt Date: October 15, 2002 DESCRIPTION The Division of Microbiology and Infectious Diseases (DMID), of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), is recompeting and expanding their current contract with the Baylor College of Medicine, Contract No. N01-AI-65298. This solicitation will be a full and open competition, NAICS Code 541710, 500 employees. This RFP solicits proposals for reference laboratories to support the infection prevention program of the Respiratory Diseases Branch, DMID. The Government has a need to continue this effort and expand reference laboratory support as part of the Bio-defense Research Agenda. The focus of these laboratories will be the development of reagents and biological assays for bacterial and viral respiratory pathogens. The Respiratory Pathogens Research Reference Laboratories will be part of a coordinated, interactive, multi-disciplinary network to help support the development of vaccines and drugs against respiratory pathogens, including those that present concerns for bio-defense and/or emerging infections. Separate proposals are solicited for separate parts of this solicitation: Part A - Bacterial Respiratory Pathogens Reference Laboratory and Part B - Viral Respiratory Reference Laboratory. An offeror may respond to either Part A or Part B, or both. It is anticipated that a total of two contracts will be awarded to successful offerors demonstrating capability of responding to the requirements of this solicitation. It is anticipated that two (2) cost-reimbursement, completion-type contracts will be awarded for a period of seven (7) years at an estimated level of effort 3.5 FTEs for each year (Part A) and 2.25 FTEs for each year (Part B). These Bacterial and Viral Research Reference Laboratories will provide a resource facility with a major effort on reagent and assay development, including distribution of procedures and reagents, for the measurement of the human immune response to targeted respiratory pathogens. The Part A reference laboratory will focus on improvement and/or development of biological assays important for studying bacterial respiratory and relevant neonatal infections as well as related vaccines (e.g., Streptococcus pneumoniae, Bordetella pertussis, Haemophilus influenzae, Neisseria meningitidis, group A streptococcus (GAS), group B streptococcus (GBS), Chlamydia pneumoniae, Mycoplasma pneumoniae, Pseudomonas aeruginosa, and Burkholderia cepacia.). The contract will provide a resource for assays and reagents, such as antigens, standard reference sera, and quality control samples and serve as a repository for their storage and distribution. Further, analytical methods will be developed, evaluated, and validated to accurately compare immunogenicity results within and between laboratories for different vaccines. The Part B reference laboratory will focus on improvement and/or development of biological assays important for studying viral respiratory and relevant neonatal infections as well as related vaccines (e.g., influenza, respiratory syncytial virus (RSV), parainfluenza, adenoviruses, rhinoviruses, and coronaviruses). The contract will provide a resource for assays and reagents, such as antigens, standard reference sera, and quality control samples and serve as a repository for their storage and distribution. Further, analytical methods will be developed, evaluated, and validated to accurately compare immunogenicity results within and between laboratories for different vaccines. Once awarded, the Respiratory Pathogens Reference Laboratories will become a part of a multi-disciplinary Respiratory Pathogens Research Network (RPPN). This network will include contracts for Respiratory Pathogens Research Units that support basic and clinical research involving bacterial and viral respiratory pathogens. The Respiratory Pathogens Research Units will be awarded through a separate solicitation entitled "Basic and Clinical Approaches to Controlling Human Respiratory Pathogens", RFP-NIH-NIAID-DMID- 03-05 that is also posted at this time. RFP-NIH-DMID-03-37, will be available electronically on the CMB Homepage on or about July 16, 2002, may be accessed through the NIAID Contract Management Branch (CMB) Home Page at: http://www.niaid.nih.gov/contract and will be posted on Fed Biz Opps: www.fedbizopps.gov. Any responsible offeror may submit a proposal that will be considered by the Government. This announcement does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted. Contracting Office Address: National Institutes of Health National Institutes of Allergy and Infectious Diseases Contract Management Branch 6700-B Rockledge Drive Room 2230, MSC 7612 Bethesda, MD, 20892-7612 Point of Contact: Nancy Hershey Contracting Officer Phone 301-496-0193 Fax 301-402-0927 Email: nh11x@nih.gov Barbara Shadrick, Senior Contracting Officer Phone 301-496-7288 Fax 301-402-0972 Email: bs92y@nih.gov
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