RFP ANNOUNCEMENT: PRIMATE CORE IMMUNOLOGY – VIROLOGY LABORATORIES - NIH-
NIAID-DAIDS-03-02

Release Date:  July 22, 2002

NOTICE: NOT-AI-02-036

National Institute of Allergy and Infectious Diseases (NIAID)
 (http://www.niaid.nih.gov)

Receipt Date: October 23, 2002

DESCRIPTION

The Division of Acquired Immune Deficiency Syndrome (DAIDS) of the National 
Institute of Allergy and Infectious Diseases (NIAID), National Institutes of 
Health (NIH), is re-competing their current contract with Beth Israel 
Deaconess Medical Center, Contract Number N01-AI-85343.  This solicitation 
will be a Full and Open Competition, NAICS Code 541710, 500 employees.  This 
RFP solicits proposals for laboratories to support the vaccine and prevention 
research program of the Preclinical Research and Development Branch, DAIDS.  
The Government has a need to continue this effort and expand laboratory 
support as part of the AIDS vaccine research agenda.  The Primate Core 
Immunology and Virology Laboratories will provide resources in support of 
AIDS vaccine studies in non-human primates by conducting standardized assays 
to assess cellular and humoral immune responses of nonhuman primates to HIV 
and SIV vaccines and will also measure viral replication levels in the 
animals after viral infection.  The new Primate Core Immunology-Virology 
Laboratories also will serve as Reference Laboratories for Quality Assurance 
and Quality Control of immune and virology-based assays, to aid in the 
standardization of assays across the non-human primate AIDS research field.   
Separate proposals are solicited for separate parts of this solicitation:  
Part A - Cellular Immunology Laboratory; Part B - Humoral Immunology 
Laboratory; and Part C - Quantitative Viral Laboratory.  An offeror may 
respond to either Part A, Part B, or Part C, or may submit proposals for any 
combination of two or three parts.  It is anticipated that one (1) to four 
(4) cost-reimbursement, completion-type contracts will awarded for a period 
of seven (7) years.   Part A will focus on the conduct of assays for viral 
(SIV, HIV, SHIV) antigen-specific cellular immune responses, such as ELISPOT, 
Intracellular Cytokine Staining, CTL, and T cell proliferation assays.   Part 
B will focus on the conduct of viral (SIV, HIV, and SHIV) neutralization 
assays, with an increasing focus on assays able to assess the ability of sera 
to neutralize infection with primary isolates of HIV-1.  Part C will focus on 
the conduct of assays to quantitatively measure, with a high degree of 
sensitivity and accuracy, the plasma levels of SIV, SHIV, or HIV viral RNA in 
infected non-human primates.   Contractors for each Part A, B, and C will be 
expected to continue to develop and improve assays in order to maintain a 
state-of-the-art capability in each area.  It is anticipated that the period 
of performance for this contract will be a total of seven years.  

RFP-NIH-NIAID-DAIDS-03-02 will be available electronically on or about July 
25, 2002, may be accessed through the NIAID Contract Management Branch (CMB) 
Home Page at http://www.niaid.nih.gov/contract and will be posted on 
FedBizOpps: www.fedbizopps.gov.  Any responsible Offeror may submit a 
proposal that will be considered by the Government.  This advertisement does 
not commit the Government to award a contract.  No collect calls will be 
accepted.  No facsimile transmissions will be accepted.

Contracting Office Address:

National Institutes of Health
National Institutes of Allergy and Infectious Diseases
Contract Management Branch 
6700-B Rockledge Drive
Room 2230, MSC 7612 
Bethesda, MD, 20892-7612

Point of Contact:

Lois Eaton
Contract Specialist
Phone 301-496-0611 
Fax 301-480-5253
Email le52u@nih.gov 

Jacqueline Holden
Senior Contracting Officer
Phone 301-496-7119
Fax 301-402-0972
Email jh55b@nih.gov 

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