Myriad Prevalence Tables [61]	BRCAPRO [64,75]	BOADICEA [64,67]	Tyrer-Cuzick [76]
AJ = Ashkenazi Jewish; BOADICEA = Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm; BRCAPRO = Berry-Aguilar-Parmigiani Model; FDR = first-degree relatives; SDR = second-degree relatives
Method	Empiric data from Myriad Genetics based on family and personal history reported on requisition forms	Statistical model	Statistical model	Statistical model
Features of the Model	Proband may or may not have breast or ovarian cancer	Proband may or may not have breast or ovarian cancer	Proband may or may not have breast or ovarian cancer	Proband must be unaffected
	Considers age of breast cancer diagnosis as <50, >50	Considers exact age at breast and ovarian cancer diagnosis
	Does not consider affected relatives	Considers prior genetic testing in family (i.e., BRCA1/2 mutation negative relatives)	Considers exact age at breast and ovarian cancer diagnosis
	Does not consider number of affected relatives	Considers oophorectomy status	Includes all FDR and SDR with and without cancer	Also includes reproductive factors and body mass index to estimate breast cancer risk
	Includes AJ ancestry	Includes all FDR and SDR with and without cancer	Includes AJ ancestry
	Very easy to use	Includes AJ ancestry
Limitations	Simplified view of family structure	Requires computer software and time-consuming data entry	Requires computer software and time-consuming data entry	Designed for individuals unaffected with breast cancer
		Incorporates only FDR and SDR; may need to change proband to best capture risk	Incorporates only FDR and SDR; may need to change proband to best capture risk

References

61. Frank TS, Manley SA, Olopade OI, et al.: Sequence analysis of BRCA1 and BRCA2: correlation of mutations with family history and ovarian cancer risk. J Clin Oncol 16 (7): 2417-25, 1998.  [PUBMED Abstract]
    
    
64. Parmigiani G, Berry D, Aguilar O: Determining carrier probabilities for breast cancer-susceptibility genes BRCA1 and BRCA2. Am J Hum Genet 62 (1): 145-58, 1998.  [PUBMED Abstract]
    
    
67. Antoniou AC, Pharoah PP, Smith P, et al.: The BOADICEA model of genetic susceptibility to breast and ovarian cancer. Br J Cancer 91 (8): 1580-90, 2004.  [PUBMED Abstract]
    
    
75. Katki HA: Incorporating medical interventions into carrier probability estimation for genetic counseling. BMC Med Genet 8: 13, 2007.  [PUBMED Abstract]
    
    
76. Tyrer J, Duffy SW, Cuzick J: A breast cancer prediction model incorporating familial and personal risk factors. Stat Med 23 (7): 1111-30, 2004.  [PUBMED Abstract]