| | This journal provides immediate access to some articles. Huntington's disease: a clinical, genetic and molecular model for polyglutamine repeat disorders. P S Harper Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 957–961. PMCID: PMC1692597 Transgenic models of Huntington's disease. K Sathasivam, C Hobbs, L Mangiarini, A Mahal, M Turmaine, P Doherty, S W Davies, and G P Bates Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 963–969. PMCID: PMC1692600 From neuronal inclusions to neurodegeneration: neuropathological investigation of a transgenic mouse model of Huntington's disease S. W. Davies Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 971–979. doi: 10.1098/rstb.1999.0448.PMCID: PMC1692612 From neuronal inclusions to neurodegeneration: neuropathological investigation of a transgenic mouse model of Huntington's disease. S W Davies, M Turmaine, B A Cozens, A S Raza, A Mahal, L Mangiarini, and G P Bates Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 981–989. PMCID: PMC1692604 Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease. J H Cha, A S Frey, S A Alsdorf, J A Kerner, C M Kosinski, L Mangiarini, J B Penney, Jr, S W Davies, G P Bates, and A B Young Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 981–989. PMCID: PMC1692608 Aggregation of truncated GST-HD exon 1 fusion proteins containing normal range and expanded glutamine repeats. B Hollenbach, E Scherzinger, K Schweiger, R Lurz, H Lehrach, and E E Wanker Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 991–994. PMCID: PMC1692611 Are there multiple pathways in the pathogenesis of Huntington's disease? N Aronin, M Kim, G Laforet, and M DiFiglia Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 995–1003. PMCID: PMC1692615 Polyglutamine pathogenesis. C A Ross, J D Wood, G Schilling, M F Peters, F C Nucifora, Jr, J K Cooper, A H Sharp, R L Margolis, and D R Borchelt Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1005–1011. PMCID: PMC1692617 Properties of polyglutamine expansion in vitro and in a cellular model for Huntington's disease. A Lunkes, Y Trottier, J Fagart, P Schultz, G Zeder-Lutz, D Moras, and J L Mandel Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1013–1019. PMCID: PMC1692598 The localization and interactions of huntingtin. A L Jones Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1021–1027. PMCID: PMC1692601 Evidence for a recruitment and sequestration mechanism in Huntington's disease. E Preisinger, B M Jordan, A Kazantsev, and D Housman Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1029–1034. PMCID: PMC1692605 Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease. P H Reddy, V Charles, M Williams, G Miller, W O Whetsell, Jr, and D A Tagle Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1035–1045. PMCID: PMC1692609 Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin. A S Hackam, J G Hodgson, R Singaraja, T Zhang, L Gan, C A Gutekunst, S M Hersch, and M R Hayden Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1047–1055. PMCID: PMC1692613 A genetic model for human polyglutamine-repeat disease in Drosophila melanogaster. N M Bonini Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1057–1060. PMCID: PMC1692616 Analysis of the subcellular localization of huntingtin with a set of rabbit polyclonal antibodies in cultured mammalian cells of neuronal origin: comparison with the distribution of huntingtin in Huntington's disease autopsy brain. J C Dorsman, M A Smoor, M L Maat-Schieman, M Bout, S Siesling, S G van Duinen, J J Verschuuren, J T den Dunnen, R A Roos, and G J van Ommen Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1061–1067. PMCID: PMC1692596 Molecular pathology of dentatorubral-pallidoluysian atrophy. I Kanazawa Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1069–1074. PMCID: PMC1692599 Androgen receptor mutation in Kennedy's disease. K H Fischbeck, A Lieberman, C K Bailey, A Abel, and D E Merry Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1075–1078. PMCID: PMC1692603 Progress in pathogenesis studies of spinocerebellar ataxia type 1. C J Cummings, H T Orr, and H Y Zoghbi Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1079–1081. PMCID: PMC1692607 CAG-polyglutamine-repeat mutations: independence from gene context. J M Ordway, J A Cearley, and P J Detloff Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1083–1088. PMCID: PMC1692602 CAG repeat instability, cryptic sequence variation and pathogeneticity: evidence from different loci. M Frontali, A Novelletto, G Annesi, and C Jodice Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1089–1094. PMCID: PMC1692606 Microsatellite and trinucleotide-repeat evolution: evidence for mutational bias and different rates of evolution in different lineages. D C Rubinsztein, B Amos, and G Cooper Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1095–1099. PMCID: PMC1692610 Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies. M Goedert Philos Trans R Soc Lond B Biol Sci. 1999 June 29; 354(1386): 1101–1118. PMCID: PMC1692614 |