| | This journal provides immediate access to some articles. Research Articles Introduction. Bioinformatics: from molecules to systems David T Jones, Michael J. E Sternberg, and Janet M Thornton PMCID: PMC1609343 Finding the molecular basis of complex genetic variation in humans and mice Richard Mott PMCID: PMC1609339 Comparative genomics and genome evolution in yeasts Kenneth H Wolfe PMCID: PMC1609344 Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery Tom L Blundell, Bancinyane L Sibanda, Rinaldo Wander Montalvão, Suzanne Brewerton, Vijayalakshmi Chelliah, Catherine L Worth, Nicholas J Harmer, Owen Davies, and David Burke PMCID: PMC1609333 Exploiting protein structure data to explore the evolution of protein function and biological complexity Russell L Marsden, Juan A.G Ranea, Antonio Sillero, Oliver Redfern, Corin Yeats, Michael Maibaum, David Lee, Sarah Addou, Gabrielle A Reeves, Timothy J Dallman, and Christine A Orengo PMCID: PMC1609337 The proteome: structure, function and evolution Keiran Fleming, Lawrence A Kelley, Suhail A Islam, Robert M MacCallum, Arne Muller, Florencio Pazos, and Michael J.E Sternberg PMCID: PMC1609342 Rigorous performance evaluation in protein structure modelling and implications for computational biology John Moult PMCID: PMC1609338 Prediction and design of macromolecular structures and interactions David Baker PMCID: PMC1609347 Towards genome-scale structure prediction for transmembrane proteins Naama Hurwitz, Marialuisa Pellegrini-Calace, and David T Jones PMCID: PMC1609336 From genomes to systems: the path with yeast Stephen G Oliver PMCID: PMC1609341 Modelling in molecular biology: describing transcription regulatory networks at different scales Thomas Schlitt and Alvis Brazma PMCID: PMC1609346 Transcriptional noise and cellular heterogeneity in mammalian macrophages S Ramsey, A Ozinsky, A Clark, K.D Smith, P de Atauri, V Thorsson, D Orrell, and H Bolouri PMCID: PMC1609340 The origins and evolution of functional modules: lessons from protein complexes Jose B Pereira-Leal, Emmanuel D Levy, and Sarah A Teichmann PMCID: PMC1609335 Comparative analysis of environmental sequences: potential and challenges Konrad U Foerstner, Christian von Mering, and Peer Bork PMCID: PMC1609345 Bioinformatic challenges for the next decade(s) David Eisenberg, Edward Marcotte, Andrew D McLachlan, and Matteo Pellegrini PMCID: PMC1609334 |
