Cellular Classification
The histologic diagnosis of mycosis fungoides and the Sézary syndrome (MF/SS)
is usually difficult to determine in the initial stages of the disease and may require the
review of multiple biopsies by an experienced pathologist.
A definitive diagnosis from a skin biopsy requires the presence of MF/SS cells
(convoluted lymphocytes), a band-like upper dermal infiltrate, and epidermal
infiltrations with Pautrier abscesses (collections of neoplastic
lymphocytes). A definitive diagnosis of SS may be made from a peripheral blood
evaluation when skin biopsies are consistent with the diagnosis. Circulating Sézary cells can be confirmed by T-cell receptor gene analysis.[1]
References
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Fraser-Andrews EA, Russell-Jones R, Woolford AJ, et al.: Diagnostic and prognostic importance of T-cell receptor gene analysis in patients with Sézary syndrome. Cancer 92 (7): 1745-52, 2001.
[PUBMED Abstract]
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