Cellular Classification
The vast majority of laryngeal cancers are of squamous cell histology.
Squamous cell subtypes include keratinizing and nonkeratinizing and well-differentiated to poorly differentiated grade. A variety of nonsquamous cell
laryngeal cancers also occur.[1] These are not staged using the American Joint
Cancer Committee staging system, and their management, which is not discussed here, can
differ from that of squamous cell laryngeal cancers. In situ squamous cell
carcinoma of the larynx is usually managed by a conservative surgical procedure
such as mucosal stripping or superficial laser excision. Radiation therapy may
also be appropriate treatment of selected patients with in situ carcinoma of
the glottic larynx.[2]
References
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Mendenhall WM, Riggs CE Jr, Cassisi NJ: Treatment of head and neck cancers. In: DeVita VT Jr, Hellman S, Rosenberg SA, eds.: Cancer: Principles and Practice of Oncology. 7th ed. Philadelphia, Pa: Lippincott Williams & Wilkins, 2005, pp 662-732.
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Wang CC, ed.: Radiation Therapy for Head and Neck Neoplasms. 3rd ed. New York: Wiley-Liss, 1997.
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