Stage III Vaginal Cancer
Squamous Cell Carcinoma
Adenocarcinoma
Current Clinical Trials
Squamous Cell Carcinoma
Standard treatment options:
- Combination of interstitial, intracavitary, and external-beam radiation
therapy (EBRT). EBRT for a period of 5 to 6 weeks (including pelvic
nodes) followed by an interstitial and/or intracavitary implant for a total
tumor dose of 75 Gy to 80 Gy and a dose to the lateral pelvic wall of 55
Gy to 60 Gy.[1]
- Rarely, surgery may be combined with the above.[2]
Adenocarcinoma
Standard treatment options:
- Combination of interstitial, intracavitary, and EBRT as described for squamous cell cancer.[1]
- Rarely, surgery may be combined with the above.[2]
Current Clinical Trials
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage III vaginal cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
References
-
Perez CA, Camel HM, Galakatos AE, et al.: Definitive irradiation in carcinoma of the vagina: long-term evaluation of results. Int J Radiat Oncol Biol Phys 15 (6): 1283-90, 1988.
[PUBMED Abstract]
-
Boronow RC, Hickman BT, Reagan MT, et al.: Combined therapy as an alternative to exenteration for locally advanced vulvovaginal cancer. II. Results, complications, and dosimetric and surgical considerations. Am J Clin Oncol 10 (2): 171-81, 1987.
[PUBMED Abstract]
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