Ependymal Tumors
Grade I and II Ependymal Tumors
Anaplastic Ependymoma
Current Clinical Trials
Grade I and II Ependymal Tumors
Ependymomas (World Health Organization [WHO] grade II) and WHO grade I ependymal tumors, i.e., subependymoma and myxopapillary ependymomas, are often curable.
(Refer to the Ependymal Tumors section in the Classification section of this summary for more information.)
Standard treatment options:
- Surgery alone if the tumor is totally resectable.
- Surgery followed by radiation therapy to known or suspected residual
tumor.[1,2]
Treatment options under clinical evaluation:
- At recurrence following surgery, patients should be considered for reoperation
and radiation therapy if not previously given. Patients who have received
radiation therapy should be considered candidates for nitrosourea-based
chemotherapies and for clinical trials that evaluate new drugs and biological
response modifiers.
Anaplastic Ependymoma
Anaplastic ependymomas (WHO grade III) have variable prognoses that depend on the location and
extent of disease. Frequently, but not invariably, anaplastic ependymomas have
worse prognoses than lower grade ependymal tumors. (Refer to the Anaplastic Ependymoma section in the Classification section of this summary for more information.)
Standard treatment options:
- Surgery plus radiation therapy.[1-3]
Treatment options under clinical evaluation:
- Adjuvant chemotherapy before, during, and after radiation are treatment options
being evaluated. At recurrence, patients should be considered candidates for
nitrosourea-based chemotherapies and for clinical trials that evaluate new
drugs and biological response modifiers.
Current Clinical Trials
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with adult ependymal tumors. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
References
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Wallner KE, Wara WM, Sheline GE, et al.: Intracranial ependymomas: results of treatment with partial or whole brain irradiation without spinal irradiation. Int J Radiat Oncol Biol Phys 12 (11): 1937-41, 1986.
[PUBMED Abstract]
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Shaw EG, Evans RG, Scheithauer BW, et al.: Postoperative radiotherapy of intracranial ependymoma in pediatric and adult patients. Int J Radiat Oncol Biol Phys 13 (10): 1457-62, 1987.
[PUBMED Abstract]
-
Oya N, Shibamoto Y, Nagata Y, et al.: Postoperative radiotherapy for intracranial ependymoma: analysis of prognostic factors and patterns of failure. J Neurooncol 56 (1): 87-94, 2002.
[PUBMED Abstract]
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