Cellular Classification
The most common cell type for paranasal sinus and nasal cavity cancers is
squamous cell carcinoma. Minor salivary gland tumors comprise 10% to 15% of
these neoplasms. Malignant melanoma presents in <1% of neoplasms in
this region. Some 5% of cases are malignant lymphomas.[1,2]
Esthesioneuroepithelioma, sometimes confused with undifferentiated carcinoma or
undifferentiated lymphoma, arises from the olfactory nerves.[3]
Chondrosarcoma, osteosarcoma, Ewing sarcoma, and most soft tissue sarcomas
have been reported for this region.
Inverting papilloma is considered a low-grade benign tumor with a tendency to
recur and, in a small percentage of cases, to transform into a malignant tumor.
Midline granuloma, a progressively destructive condition, involves this region
as well.
References
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Mendenhall WM, Riggs CE Jr, Cassisi NJ: Treatment of head and neck cancers. In: DeVita VT Jr, Hellman S, Rosenberg SA, eds.: Cancer: Principles and Practice of Oncology. 7th ed. Philadelphia, Pa: Lippincott Williams & Wilkins, 2005, pp 662-732.
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Goldenberg D, Golz A, Fradis M, et al.: Malignant tumors of the nose and paranasal sinuses: a retrospective review of 291 cases. Ear Nose Throat J 80 (4): 272-7, 2001.
[PUBMED Abstract]
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Jethanamest D, Morris LG, Sikora AG, et al.: Esthesioneuroblastoma: a population-based analysis of survival and prognostic factors. Arch Otolaryngol Head Neck Surg 133 (3): 276-80, 2007.
[PUBMED Abstract]
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