Comparison of Two Combination Chemotherapy Regimens in Treating
Patients With Stage III or Stage IV Hodgkin's Lymphoma
A total of 550 patients (225 per treatment arm) will be accrued for this study within 5.5 years.
This is a randomized, multicenter study. Patients are stratified according to International Prognostic Score (3 vs 4 or more) and participating center. Patients are randomized to 1 of 2 treatment arms.
Quality of life is assessed at baseline, at the end of therapy, and then annually for 10 years.
Patients are followed every 3 months for 3 years, every 6 months for 2 years, and then annually thereafter.
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Australia |
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Australian Capital Territory |
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Woden |
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| Canberra Hospital |
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New South Wales |
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Kingswood |
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| Nepean Cancer Care Centre at Nepean Hospital |
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Westmead |
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| Westmead Institute for Cancer Research at Westmead Hospital |
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Queensland |
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Brisbane |
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| Princess Alexandra Hospital |
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Victoria |
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East Melbourne |
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| Peter MacCallum Cancer Centre |
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| Contact Person | |
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| Max Wolf, MD | |
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Fitzroy |
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| St. Vincent's Hospital - Melbourne |
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Western Australia |
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Perth |
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| Royal Perth Hospital |
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Belgium |
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Antwerp |
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| Ziekenhuis Netwerk Antwerpen Middelheim |
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Brugge |
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| AZ Sint-Jan |
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Brussels |
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| Centre Hospitalier Universitaire Brugmann |
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| Cliniques Universitaires Saint-Luc |
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| Hopital Universitaire Erasme |
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| Institut Jules Bordet |
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Charleroi |
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| Centre Hospitalier Notre Dame - Reine Fabiola |
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Edegem |
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| Universitair Ziekenhuis Antwerpen |
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Ghent |
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| Algemeen Ziekenhuis Sint Lucas |
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Haine Saint Paul |
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| Hopital de Jolimont |
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Leuven |
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Liege |
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| Centre Hospitalier Regional de la Citadelle |
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Mont-Godinne Yvoir |
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| Clinique Universitaire De Mont-Godinne |
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Roeselare |
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| H. Hartziekenhuis - Roeselaere. |
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Canada |
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Alberta |
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Calgary |
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| Tom Baker Cancer Centre - Calgary |
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| Contact Person | |
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| Douglas A. Stewart | |
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Edmonton |
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| Cross Cancer Institute at University of Alberta |
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| Contact Person | |
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| Neil Sun Chua | |
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Manitoba |
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Winnipeg |
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| CancerCare Manitoba |
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| Contact Person | |
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| Matthew D. Seftel | |
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| Centre Hospitalier De Dunkerque - CHD |
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New Brunswick |
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Moncton |
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| Moncton Hospital |
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| Contact Person | |
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| Sheldon Rubin | |
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Newfoundland and Labrador |
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St. Johns |
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| Doctor H. Bliss Murphy Cancer Centre |
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St. John's |
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| Doctor H. Bliss Murphy Cancer Centre |
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| Grenfell Adams | |
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Nova Scotia |
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Halifax |
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| Nova Scotia Cancer Centre |
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| Contact Person | |
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| Wanda S. Hasegawa | |
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Ontario |
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Kingston |
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| Cancer Centre of Southeastern Ontario at Kingston General Hospital |
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| Contact Person | |
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| Tara Baetz | |
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London |
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| London Regional Cancer Program at London Health Sciences Centre |
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| Contact Person | |
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| Kang Howson-Jan | |
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Ottawa |
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| Ottawa Hospital Regional Cancer Centre - General Campus |
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| Isabelle Bence-Bruckler | |
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Sudbury |
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| Northeastern Ontario Regional Cancer Centre |
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| Contact Person | |
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Toronto |
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| Edmond Odette Cancer Centre at Sunnybrook |
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| Contact Person | |
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| Rena Buckstein | |
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| Princess Margaret Hospital |
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| Contact Person | |
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| Michael Crump | |
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Windsor |
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| Windsor Regional Cancer Centre at Windsor Regional Hospital |
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Quebec |
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Greenfield Park |
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| Hopital Charles Lemoyne |
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| Pierre Desjardins | |
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Montreal |
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| CHUM - Hotel Dieu Hospital |
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| Hopital Notre-Dame du CHUM |
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| Harold J. Olney | |
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| Maisonneuve-Rosemont Hospital |
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| Contact Person | |
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| McGill Cancer Centre at McGill University |
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| Ahmed Galal | |
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Quebec City |
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| Centre Hospitalier Universitaire de Quebec |
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| Contact Person | |
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| Hopital du Saint-Sacrement - Quebec |
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| Guy Cantin | |
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Saskatchewan |
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Saskatoon |
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| Saskatoon Cancer Centre at the University of Saskatchewan |
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| Michael Voralia | |
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Croatia |
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Zagreb |
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| University Hospital Rebro |
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Czech Republic |
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Prague |
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| Thomayer's University Hospital |
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France |
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Annecy |
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| Centre Hospitalier d'Annecy |
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Bayonne |
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| Centre Hospitalier de la Cote Basque |
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Besancon |
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| Centre Hospitalier Regional de Besancon - Hopital Jean Minjoz |
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Bordeaux |
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| Institut Bergonie |
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Boucher |
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| Polyclinique Bordeaux Nord Aquitaine |
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Bourg En Bresse |
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| C.H. Bourg En Bresse |
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Caen |
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| Centre Regional Francois Baclesse |
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| CHU de Caen |
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| Polyclinique Du Parc |
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Chambery |
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| Centre Hospitalier Regional de Chambery |
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Clamart |
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| Hopital Antoine Beclere |
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| Hopital d'Instruction des Armees Percy |
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Clermont-Ferrand |
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| CHR Clermont Ferrand, Hotel Dieu |
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Colmar |
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| Hopital Louis Pasteur |
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Corbeil |
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| Centre Hospitalier Sud Francilien - Site Corbeil |
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Creteil |
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| Centre Hospitalier Universitaire Henri Mondor |
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Dijon |
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| Hopital Du Bocage |
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Grenoble |
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| Institut Prive de Cancerologie |
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Le Chesnay |
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| Hopital Andre Mignot |
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Lille |
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| Centre Hospitalier Regional et Universitaire de Lille |
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| Contact Person | |
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| Hopital Saint Antoine Lille |
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Limoges |
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| Centre Hospital Regional Universitaire de Limoges |
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Lyon |
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| Centre Leon Berard |
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| Hopital Edouard Herriot - Lyon |
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Marseille |
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| Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes |
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Meaux |
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| Centre Hospitalier de Meaux |
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Melun |
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| Centre Hospitalier Marc Jacquet |
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Metz |
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| Hopital Notre-Dame de Bon Secours |
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| Contact Person | |
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Montpellier |
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| Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle |
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Mulhouse |
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| Centre Hospitalier de Mulhouse |
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Nice |
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| Centre Antoine Lacassagne |
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| Hopital de l'Archet CHU de Nice |
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Paris |
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| CHU Pitie-Salpetriere |
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| Hopital Cochin |
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| Hopital Necker |
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| Hopital Saint Antoine |
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| Hopital Saint-Louis |
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| Hotel Dieu de Paris |
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| Institut Curie Hopital |
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Pessac |
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| Hopital Haut Leveque |
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Pierre Benite |
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| Centre Hospitalier Lyon Sud |
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Pontoise |
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| Hopital Rene Dubos |
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Reims |
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| Institut Jean Godinot |
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Rennes |
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| Hopital Sud |
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Rouen |
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| Centre Henri Becquerel |
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Saint Cloud |
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| Centre Rene Huguenin |
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Saint Etienne |
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| CHU Sainte-Etienne - Hopital Bellevue |
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Saint Germain-en-Laye |
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| Hopital de Saint Germain-en-Laye |
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Strasbourg |
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| Hopital Universitaire Hautepierre |
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Suresnes |
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| Hopital Foch |
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Valence |
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| Centre Hospitalier Valence |
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Valenciennes |
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| Centre Hospitalier de Valenciennes |
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Vandoeuvre-Les-Nancy |
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| CHU de Nancy - Hopitaux de Brabois |
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Villejuif |
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| Hopital Paul Brousse |
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| Contact Person | |
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| Institut Gustave Roussy |
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Hungary |
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Budapest |
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| National Institute of Oncology |
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Netherlands |
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Amersfoort |
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| Meander Medisch Centrum |
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Amsterdam |
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| Academisch Medisch Centrum at University of Amsterdam |
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| Contact Person | |
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| Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital |
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| Contact Person | |
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| Onze Lieve Vrouwe Gasthuis |
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Delft |
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| Reinier de Graaf Group - Delft |
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Enschede |
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| Medisch Spectrum Twente |
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Groningen |
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| University Medical Center Groningen |
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Heerlen |
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| Atrium Medical Centre - Heerlen |
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| Contact Person | |
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Leiden |
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| Leiden University Medical Center |
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Maastricht |
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| Academisch Ziekenhuis Maastricht |
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Nijmegen |
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| Universitair Medisch Centrum St. Radboud - Nijmegen |
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Roermond |
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| Saint Laurentius Ziekenhuis |
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Rotterdam |
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| Daniel Den Hoed Cancer Center at Erasmus Medical Center |
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's-Gravenhage |
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| HagaZiekenhuis - Locatie Leyenburg |
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's-Hertogenbosch |
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| Jeroen Bosch Ziekenhuis |
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Utrecht |
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| University Medical Center Utrecht |
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New Zealand |
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Auckland |
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Hamilton |
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Poland |
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Warsaw |
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| Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology - Warsaw |
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Spain |
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Barcelona |
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| Hospital Clinic de Barcelona |
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| Contact Person | Ph: | 34-93-227-5400 ext. 2262 | | |
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| Hospital de la Santa Cruz i Sant Pau |
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| Anna Sureda | |
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| Hospital Universitari Germans Trias i Pujol |
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Sweden |
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Gothenburg (Goteborg) |
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| Sahlgrenska University Hospital |
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Linkoping |
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| University Hospital of Linkoping |
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Lund |
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| Lund University Hospital |
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Stockholm |
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| Karolinska University Hospital - Huddinge |
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Umea |
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| Umea Universitet |
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Uppsala |
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United Kingdom |
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England |
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Birmingham |
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| Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust |
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Canterbury |
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Hull |
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Kettering, Northants |
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Leicester |
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| Leicester Royal Infirmary |
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London |
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| Middlesex Hospital |
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| David C. Linch | |
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Northwood |
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| Mount Vernon Cancer Centre at Mount Vernon Hospital |
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Nottingham |
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| Nottingham City Hospital NHS Trust |
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Sheffield |
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| Cancer Research Centre at Weston Park Hospital |
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Stafford |
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