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Table 2. AJCC Staging System for Soft Tissue Sarcomasa
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Primary Tumorb
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Regional Lymph Nodes
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Distant Metastasis
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Histologic Gradec
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Stage I
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Any tumor size, superfical or deep |
N0 |
M0 |
G1 |
G2 |
Stage II
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T1a (tumor ≤5 cm in maximal diameter, superficial) |
N0 |
M0 |
G3 |
T1b (tumor ≤5 cm in maximal diameter, deep) |
N0 |
M0 |
G3 |
T2a (tumor >5 cm in maximal diameter, superficial) |
N0 |
M0 |
G3 |
Stage III
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T2b (tumor >5 cm in maximal diameter, deep) |
N0 |
M0 |
G3 |
Stage IV
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Any tumor size, superfical or deep |
N1 |
M0 or M1 |
G1, G2, or G3 |
Any tumor size, superfical or deep |
N0 or N1 |
M1 |
G1, G2, or G3 |
G1 = well differentiated; G2 = moderately differentiated; G3 = poorly differentiated; M0 = no distant metastasis; M1 = distant metastasis; N0 = no regional lymph node metastasis; N1 = regional lymph node metastasis
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aAdapted from AJCC Cancer Staging Manual.[10]
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bSuperficial tumor is located above the superficial fascia without invasion of the fascia; deep tumor is located either exclusively beneath the superficial fascia or superficial to the fascia with invasion of or through the fascia. All intraperitoneal visceral lesions, retroperitoneal, pelvic, and intrathoracic tumors, and the majority of head and neck tumors are classified as deep tumors.
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cThe histologic grade established by central pathology review is to be used for staging purposes.
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References
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American Joint Committee on Cancer.: AJCC Cancer Staging Manual. 6th ed. New York, NY: Springer, 2002.
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