 |
|
|
Table 1. Frequent Aberrations Seen In Nonrhabdomyosarcomatous Soft Tissue
Tumorsa
|
Histology
|
Chromosomal Aberrations
|
Genes Involved
|
| Alveolar soft part sarcoma |
t(x;17)(p11.2;q25) |
ASPL/TFE3 [4-6] |
| Clear cell sarcoma (malignant melanoma of soft parts) |
t(12;22)(q13;q12) |
ATF1/EWS
|
| Congenital fibrosarcoma/ mesoblastic nephroma |
t(12;15)(p13,q25) [4] |
ETV-NTRK3 [4] |
| Dermatofibrosarcoma |
t(17;22)(q22;q13) |
COL1A1/PDGFB
|
| Desmoplastic small round cell tumors |
t(11;22)(p13;q12) |
WT1/EWS [7] |
| Extraskeletal myxoid chondrosarcoma |
t(9;22)(q22;q12) |
EWS-CHN
|
| Hemangiopericytoma |
t(12;19)(q13;q13.3) and
t(13;22)(q22;q13.3) |
|
| Infantile fibrosarcoma |
t(12;15);+11; also +8,+17,+20 |
ETVG(TEL)/NTRK3
|
| Leiomyosarcoma |
t(12;14) |
|
| Low-grade fibromyxoid sarcoma |
t(7;16)(q33;p11) |
FUS/BBF2H7 |
| Malignant fibrous histiocytoma |
19p+, ring chromosome |
|
| Myxoid liposarcoma |
t(12;16)(q13;p11) |
FUS/CHOP
|
| Neurofibrosarcoma |
Deletion 17q11.2 |
|
| Rhabdoid tumor |
t(1;22)(p36:q11.2) [4] |
SNFS/INI1 [4] |
| Synovial sarcoma |
t(x;18)(p11.2;q11.2) |
SYT/SSX
|
|
aAdapted from Sandberg [3] and Slater et al.[4]
|
|
|
References
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Sandberg AA: Translocations in malignant tumors. Am J Pathol 159 (6): 1979-80, 2001.
[PUBMED Abstract]
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Slater O, Shipley J: Clinical relevance of molecular genetics to paediatric sarcomas. J Clin Pathol 60 (11): 1187-94, 2007.
[PUBMED Abstract]
-
Ladanyi M: The emerging molecular genetics of sarcoma translocations. Diagn Mol Pathol 4 (3): 162-73, 1995.
[PUBMED Abstract]
-
Barnoud R, Sabourin JC, Pasquier D, et al.: Immunohistochemical expression of WT1 by desmoplastic small round cell tumor: a comparative study with other small round cell tumors. Am J Surg Pathol 24 (6): 830-6, 2000.
[PUBMED Abstract]
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