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- Visualisation and Quantification of Morphogen Gradient Formation in the Zebrafish
- Evolution of Complex RNA Polymerases: The Complete Archaeal RNA Polymerase Structure
- Direct Observation of ATP-Induced Conformational Changes in Single P2X4 Receptors
- Stress-Dependent Coordination of Transcriptome and Translatome in Yeast
- Reawakening Retrocyclins: Ancestral Human Defensins Active Against HIV-1
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Weekly Editors' Picks
The New Yeast Is a Mouse!
Recombination hotspots are determined not only by features of the local genome but also by sequences acting at a considerable distance both in cis and trans.
Read the article. Read the related Parvanov et al. paper. Read the related Grey et al. paper.
Rousing a Latent Defense Mechanism to Fight HIV
Repairing an ancestral human pseudogene by mutagenesis, or by the application of aminoglycosides to suppress the termination codon, can restore the production of retrocyclins, which are peptides of the defensin family that are remarkable inhibitors of HIV-1 entry into cells.
Abl Is Able to Inhibit Cell Engulfment
Authors Horvitz, et al., show that C. elegans Abl (ABL-1) inhibits the engulfment of apoptotic cells via a newly defined pathway that includes the C. elegans homolog of the cytoskeletal regulator Abl-interactor.
How to Make Evolution-Proof Insecticides for Malaria Control
The evolution of resistance to insecticides by mosquitoes is a major threat to ongoing malaria control programs and plans for global eradication. Evolutionary theory suggests a practical solution.
Fishing for Prion Protein Function
The prion protein is infamous for its role in devastating neurological diseases, but its normal, physiological function has remained mysterious. A new study uses the experimentally tractable zebrafish model to obtain fresh clues to this puzzle.
Gene Sharing Yields an Enzyme with Two Binding Sites in One Subunit
The active of site of an esterase enzyme has acquired a noncatalytic carbohydrate-binding function without compromising its catalytic activity, providing support for the "gene sharing" model of protein diversification.
April 2009 Issue
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