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(... FYOO-zhun JEEN)
| A gene formed when pieces of chromosomes 9 and 22 break off and trade places. The ABL gene from chromosome 9 joins to the BCR gene on chromosome 22, to form the BCR-ABL fusion gene. The changed chromosome 22 with the fusion gene on it is called the Philadelphia chromosome. The BCR-ABL fusion gene is found in most patients with chronic myelogenous leukemia (CML), and in some patients with acute lymphoblastic leukemia (ALL) or acute myelogenous leukemia (AML). |
Previous Definitions: | BBR 3464, BCG, BCG solution, bcl-2 antisense oligodeoxynucleotide G3139, BCL2 | Next Definitions: | BCR-ABL fusion protein, BCX-1777, BDC, BEACOPP, BEACOPP regimen |
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