Basic Trial Information
Trial Description
     Summary
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase II	Treatment	Active	18 to 75	Other	IELSG20 NCT00210314

Trial Description

Summary

Aim of the study is to establish in a prospective, randomized clinical trial the activity of primary chemotherapy containing high dose-methotrexate, alone or combined with high dose cytarabine, in patients with primary central nervous system lymphoma

Eligibility Criteria

Inclusion Criteria:

1. Histological or cytological diagnosis of non-Hodgkin's lymphoma.

2. Diagnostic sample obtained by stereotactic or surgical biopsy, CSF cytology examination or vitrectomy.

3. Disease exclusively localized into the central nervous system, cranial nerves or eyes.

4. Untreated patients (patients treated with steroids alone are eligible).

5. At least one measurable lesion.

6. Age 18 - 75 years.

7. ECOG performance status < 3

8. HBsAg-negative and Ab anti-HCV-negative serologic status.

9. No known HIV disease or immunodeficiency.

10. Adequate bone marrow (PLT > 100000 mm3, Hb ≥ 9 g/dl, ANC ≥ 2.000 mm3), renal (creatinine clearance ≥ 60 mL/min), cardiac (VEF ≥ 50%), and hepatic function (total serum bilirubin < 3 mg/dL, AST/ALT and gGT < 2 per upper normal limit value).

11. No previous or concurrent malignancies with the exception of surgically cured cervical intraepithelial neoplasia type 1 (CIN1) or localized non-melanomatous skin cancer and of other cancers without evidence of disease since at least 5 years (patients with a previous lymphoma diagnosis will be excluded).

12. Absence of any familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule.

13. Non-pregnant and non-lactating status for female patients. Adequate contraceptive measures during study participation for sexually active patients of childbearing potential.

14. No concurrent treatment with other experimental drugs.

15. Informed consent signed by the patient before registration

Trial Contact Information

Trial Lead Organizations/Sponsors

International Extranodal Lymphoma Study Group

Andres JM Ferreri, MD

Study Chair

Michele Reni, MD

Study Chair

Emanuele Zucca, MD

Study Chair

Cristina Morinini		Ph: +41 91 8119040
		Email: ielsg@ticino.com

Switzerland
	Bellinzona
	Oncology Institute of Southern Switzerland
		Cristina Morinini	Ph: +41 91 8119040
			Email: ielsg@ticino.com

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00210314
Information obtained from ClinicalTrials.gov on March 18, 2009