 |
|
|
Table 1. Percentage of Patients with Clinical Features of MEN 2 by Subtype
|
Subtype
|
Medullary Thyroid
Carcinoma (%)
|
Pheochromocytoma (%)
|
Parathyroid Disease (%)
|
| MEN 2A |
95 |
50 |
20-30 |
| FMTC |
~100 |
0 |
0 |
| MEN 2B |
100 |
50 |
Uncommon |
|
FMTC = familial medullary thyroid carcinoma
|
|
Percentages based on observations in referral populations.[4-6]
|
References
-
Eng C: Seminars in medicine of the Beth Israel Hospital, Boston. The RET proto-oncogene in multiple endocrine neoplasia type 2 and Hirschsprung's disease. N Engl J Med 335 (13): 943-51, 1996.
[PUBMED Abstract]
-
Ponder BA: Multiple endocrine neoplasia type 2. In: Vogelstein B, Kinzler KW, eds.: The Genetic Basis of Human Cancer. 2nd ed. New York, NY: McGraw-Hill, 2002, pp 501-513.
|
|
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