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Sleep Disorders (PDQ®)
Patient Version   Health Professional Version   En español   Last Modified: 09/09/2008
Medications Commonly Used To Promote Sleep

Drug category   Medication   Hypnotic dose (route)   Onset (duration of action) 
Benzodiazepines diazepam (Valium) 5–10 mg (capsule, tablet) 30–60 min (6–8 h)
temazepam (Restoril) 15–30 mg (capsule) 60 min, minimum (6–8 h)
triazolam (Halcion) 0.125–0.5 mg (tablet) 30 min (peaks 1–1.5 h)
clonazepam (Klonopin) 0.5–2.0 mg (tablet) 30–60 min (8–12 h)
Tricyclic antidepressants doxepin (Sinequan) 10–150 mg 30 min
amitriptyline (Elavil) 10–15 mg 30 min
nortriptyline (Pamelor) 10–50 mg 30 min
Chloral derivatives chloral hydrate 0.5–1.0 g (capsule, syrup, suppository) 30–60 min (4–8 h)
Second-generation antidepressants trazodone (Desyrel) 25–150 mg 30 min
nefazodone (Serzone) 50–100 mg 30 min
mirtazapine (Remeron) 15–60 mg 30 min
Antihistamines diphenhydramine (Benadryl) 25–100 mg (tablet, capsule, syrup) 10–30 min (4–6 h)
hydroxyzine (Vistaril, Atarax) 10–100 mg (tablet, capsule, syrup) 15–30 min (4–6 h)
Neuroleptics thioridazine (Mellaril) 10–50 mg 30–60 min
chlorpromazine (Thorazine) 10–50 mg 30–60 min
Other zolpidem tartrate (Ambien) 5–20 mg 30 min (4–6 h)
zaleplon (Sonata) 10–20 mg 30 min (4–6 h)


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