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Cytarabine This page contains brief information about cytarabine and a collection of links to more information about the use of this drug, related research results, and ongoing clinical trials. US Brand Name(s): | | Cytosar-U | | | | Tarabine PFS | | | FDA Approved: | | Yes |
Cytarabine is approved by the Food and Drug Administration (FDA) to be given as intrathecal therapy to prevent and treat meningeal leukemia (leukemia that has spread to the meninges). Cytarabine is also approved to be used together with other drugs to treat the following conditions: Cytarabine is being studied in the treatment of other types of cancer.
Cytarabine is also available in a different form called liposomal cytarabine. For more information, see the Drug Information Summary for Liposomal Cytarabine 4. Information from the NCIDefinition from the NCI Drug Dictionary 5 - Detailed scientific definition and other names for this drug.
Clinical Trial Results: Low-Dose Cytarabine Improves Survival of Older Patients with Leukemia (03/27/2007) 6 - Important clinical trial results for this drug, background information, and how the trial was done.
Information from the National Library of Medicine (NLM)
MedlinePlus Information on Cytarabine 7 - A lay language summary of important information about this drug that may include the following:
- warnings about this drug,
- what this drug is used for and how it is used,
- what you should tell your doctor before using this drug,
- what you should know about this drug before using it,
- other drugs that may interact with this drug, and
- possible side effects.
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This NLM patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied. Clinical TrialsClinical Trials for Cytarabine 8 - Check for trials from NCI's PDQ Cancer Clinical Trials Registry now accepting patients.
Important: The drug information on this Web page is meant to be educational. It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.
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Glossary Terms
acute lymphoblastic leukemia (uh-KYOOT LIM-foh-BLAS-tik loo-KEE-mee-uh)
An aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow. Also called acute lymphocytic leukemia and ALL.
acute myeloid leukemia (uh-KYOOT MY-eh-loyd loo-KEE-mee-uh)
An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood. Also called acute myeloblastic leukemia, acute myelogenous leukemia, acute nonlymphocytic leukemia, AML, and ANLL.
cancer (KAN-ser)
A term for
diseases in which abnormal cells divide without control and
can invade nearby tissues. Cancer cells can also spread to
other parts of the body through the blood and lymph
systems. There are several main types of cancer. Carcinoma
is cancer that begins in the skin or in tissues that line
or cover internal organs. Sarcoma is cancer that begins in
bone, cartilage, fat, muscle, blood vessels, or other
connective or supportive tissue. Leukemia is cancer that
starts in blood-forming tissue such as the bone marrow, and
causes large numbers of abnormal blood cells to be produced
and enter the blood. Lymphoma and multiple myeloma are
cancers that begin in the cells of the immune system.
Central nervous system cancers are cancers that begin in
the tissues of the brain and spinal cord.
chronic myelogenous leukemia (KRAH-nik MY-eh-LAH-jeh-nus loo-KEE-mee-uh)
A slowly progressing disease in which too many white blood cells (not lymphocytes) are made in the bone marrow. Also called chronic granulocytic leukemia, chronic myeloid leukemia, and CML.
drug
Any substance, other than food, that is used to prevent, diagnose, treat or relieve symptoms of a disease or abnormal condition. Also refers to a substance that alters mood or body function, or that can be habit-forming or addictive, especially a narcotic.
FDA
An
agency in the U.S. federal government whose mission is to
protect public health by making sure that food, cosmetics,
and nutritional supplements are safe to use and truthfully
labeled. The FDA also makes sure
that drugs, medical devices, and equipment are safe and
effective, and that blood for transfusions and transplant
tissue are safe. Also called Food and Drug Administration.
intrathecal chemotherapy (IN-truh-THEE-kul KEE-moh-THAYR-uh-pee)
Treatment in which anticancer drugs are injected into the fluid-filled space between the thin layers of tissue that cover the brain and spinal cord.
leukemia (loo-KEE-mee-uh)
Cancer that starts in blood-forming tissue such as the bone marrow and causes large numbers of blood cells to be produced and enter the bloodstream.
liposomal (LY-poh-SOH-mul)
A drug preparation that contains the active drug inside very tiny, fat-like particles. This form is easier for the body to absorb and allows more drug to get to the target area of the body, such as a tumor. Liposomal drugs may have fewer side effects and work better than other forms of the drug.
meningeal (meh-NIN-jee-ul)
Having to do with the meninges (three thin layers of tissue that cover and protect the brain and spinal cord).
prevention (pree-VEN-shun)
In medicine, action taken to decrease the chance of getting a disease or condition. For example, cancer prevention includes avoiding risk factors (such as smoking, obesity, lack of exercise, and radiation exposure) and increasing protective factors (such as getting regular physical activity, staying at a healthy weight, and having a healthy diet).
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Table of Links
1 | http://www.cancer.gov/cancertopics/druginfo/alphalist |
2 | http://www.cancer.gov/clinicaltrials/learning/approval-process-for-cancer-drugs |
3 | http://www.cancer.gov/cancertopics/factsheet/Therapy/investigational-drug-access |
4 | http://www.cancer.gov/cancertopics/druginfo/liposomalcytarabine |
5 | http://www.cancer.gov/Templates/drugdictionary.aspx?CdrID=39015 |
6 | http://www.cancer.gov/clinicaltrials/results/cytarabine0307 |
7 | http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682222.html |
8 | http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39015&idtype=1 |
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